Nature Biotechnology August 2012 Cover Creating an artificial jellyfish to model the human heartRegular blog readers will know I think tissue engineering is an exciting area where you can see innovation in action – advances in basic science can translate into ways to artificially create replacement organs and body parts.

Research published online 22 July 2012 in Nature Biotechnology by Janna Nawroth and colleagues at the California Institute of Technology (Caltech) and Harvard University, shows how biomedical engineers are learning from the structure and function of other animals.

In a Nature Biotechnology article titled “a tissue-engineered jellyfish with biomimetic propulsion” researchers describe how they were able to combine rat cardiac muscle cells and a synthetic elastomer membrane into a medusoid like structure that mimicked the propulsion of a jellyfish.
jelly artificial color 150x150 Creating an artificial jellyfish to model the human heart

Credit: Caltech and Harvard University

They achieved this by forming the elastomer into a medusoid or jellyfish like shape with eight lobes around a central disc, then applying a monolayer of rat cardiac muscle tissue, which when electrically shocked, contracted in a synchronized way.

The net result was the medusoid “swam” in a similar way to a jellyfish. They effectively developed an artificial pump made out of a hybrid of living cells and silicone rubber.

The video below by Janna Nawroth, produced by Caltech and Harvard University, shows the medusoid in action, and explains how this research advances the design of muscular pumps for biomedical application:

According to the Caltech press release, this approach in reverse-engineering the function of a jellyfish “will be broadly applicable to the reverse engineering of muscular organs in humans.” 

While we are not yet able to tissue engineer a replacement human heart, it’s hard not to believe that at some point in the future we will see the development of hybrid devices that combine synthetic materials and cultured heart muscle cells.

Reference

rb2 large gray Creating an artificial jellyfish to model the human heartJanna C Nawroth, Hyungsuk Lee, Adam W Feinberg, Crystal M Ripplinger, Megan L McCain, Anna Grosberg, John O Dabiri, & Kevin Kit Parker (2012). A tissue-engineered jellyfish with biomimetic propulsion Nature Biotechnology, 30, 792-797 DOI: 10.1038/nbt.2269

 Creating an artificial jellyfish to model the human heart

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