Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology & Hematology

About MaverickNY

Here are my most recent posts

Posts by MaverickNY

How Syros are changing biotech R&D

We have written about small biotechs and big pharma a lot on this blog, particularly when they have exciting new developments in their pipeline to review and consider.  Increasingly, we have also begun to look at the early phase companies because often, that is where some fresh ideas and approaches are being developed and tested.

Leave a comment

Will Bluebird Bio transform beta Thalassemia and Sickle Cell Anemia?

Beta thalassemia isn’t something you read much about in the medical lay press, at least until recently.  Part of the problem is the lack of approved therapies, as well as the dearth of new products being evaluated in this condition.  It’s also more common in the Mediterranean, Middle East and Asia compared to the US, where it’s medical cousin, sickle cell anemia, dominates.

Leave a comment

Biomarin PARP inhibitor talazoparib shows promise in gBRCA Breast Cancer

The DNA in a human cell undergoes thousands damaging events per day, generated by both external (exogenous) and internal metabolic (endogenous) processes. Unfortunately, some of these changes can generate errors in the transcription of DNA and subsequent translation into proteins necessary for signaling and cellular function. Genomic mutations can also be carried over into future generations of cells, if the mutation is not repaired prior to mitosis.

Leave a comment

Top 10 AML abstracts at ASH 2014

San Francisco F line Trolley originally from MilanSan Francisco – Acute Myeloid Leukemia (AML) is largely a disease of the elderly since it is uncommon before the age of 45. It generally has a much poorer prognosis compared to other leukemias such as CML and even ALL. There are two main treatment options – high chemotherapy (ara-C is the main bedrock) or a stem cell transplant in those patients who are considered eligible. With the average age at diagnosis being ~66yo, many patients may be elderly and frail, making a SCT not a viable option.

Leave a comment