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Posts by Pieter Droppert

Urologist Castrates Media over Reporting of PIVOT Prostate Cancer Trial

Dr Benjamin J. Davies, an academic urologist at the University of Pittsburgh today castrated the media over their coverage of the Prostate Cancer Intervention versus Observation Trial (PIVOT).

WILT EAU 2012 PIVOT Trial Urologist Castrates Media over Reporting of PIVOT Prostate Cancer Trial

In an article titled “Prostate Cancer: Lessons from PIVOT lost in media hype” published in the News and Views section of Nature Reviews Urology, Dr Davies states, “we must be careful to ensure the less-newsworthy facts and limitations of high-profile trials, such as PIVOT, are not lost in the media hype.

Davies goes on to say,

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NEJM reports trial of Veracyte thyroid cancer diagnostic test, is it worth $4,200?

Detecting thyroid cancer early and avoiding unnecessary surgery is the potential promise of a new cancer diagnostic test, known as the Afirma® gene expression classifier test, developed by South San Francisco company, Veracyte.

nci vol 2247 72 300x200 NEJM reports trial of Veracyte thyroid cancer diagnostic test, is it worth $4,200?

Human thyroid with cancer nodules.
Photo Credit: Dr Jeffrey Norton/NCI

According to the American Society of Cancer (ACS), with 56,540 cases expected this year, thyroid cancer is the fastest increasing cancer in the United States.

The most common symptom of thyroid cancer is a lump or nodule in the neck. To diagnose cancer, cells are taken by a fine needle from the nodule and examined to see if they are malignant (cancerous) or benign (not cancerous).

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Biosimilars could be a casualty of Supreme Court Health Care Decision

The decision expected this Thursday by the Supreme Court of the United States on the constitutionality of the Patient Protection and Affordable Care Act (PPACA) may impact the development and approval of biosimilars.

United States Capitol Building 300x225 Biosimilars could be a casualty of Supreme Court Health Care DecisionPart of the PPACA signed into law by President Obama on March 23, 2010 was the Biologics Price Competition & Innovation Act (BPCI).

This amended the Public Health Service Act (PHS) to create a pathway under section 351(k) for the licensing of biological products that are “interchangeable” or “biosimilar” to an FDA-licensed product.

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BAY 86-9766 shows early promise at AACR Pancreatic Cancer Conference

A diagnosis of stage IV pancreatic cancer is pretty much a death sentence.

People are often diagnosed in the advanced stage of the disease – 49.5% are diagnosed in stage IV – and the prognosis is generally not good.  Sadly most don’t live long, even with the latest treatments.

According to the National Cancer Institute (NCI) SEER survival monograph, the relative survival rates are extremely poor. Across all types of pancreatic cancer, only 5% of people live for 5 years, and only 23% survive 1 year.  Three to five months is the median survival time for those with untreated metastatic pancreatic cancer.

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Problems with Alpharadin ASCO SRE data?

ASCO 2012 Alpharadin Sartor Poster Time to First SRE 300x163 Problems with Alpharadin ASCO SRE data?

At the 2012 American Society of Clinical Oncology (ASCO) annual meeting, data was presented by Dr Oliver Sartor (ASCO 2012 Abstract 4551) that showed radium-223 (Alpharadin) significantly delayed time to first skeletal-related event (SRE) in patients with castratation-resistant prostate cancer (CRPC) and bone metastases.

The SRE data for radium-223 from the ALSYMPCA phase III trial was first presented at ASCO GU earlier this year.

ASCO 2012 radium-223 data discrepancies

Algeta in a communication I received today, however, have advised that the data contained in the ASCO 2012 abstracts has “discrepancies.”  In the absence of more precise information, the discrepancies may or may not be significant.

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ASCO 2012 What is the Optimal Sequencing of Advanced Prostate Cancer Drugs?

At the 2012 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, Oliver Sartor, Professor of Cancer Research and Medical Director of the Tulane Cancer Center in New Orleans told attendees in the educational session on castration-resistant prostate cancer (CRPC) that he was tired of being asked the question of what is the optimal sequence for new advanced prostate cancer drugs?

Oliver Sartor ASCO 2012 ASCO 2012 What is the Optimal Sequencing of Advanced Prostate Cancer Drugs?There is “No data,” Sartor told the ASCO 2012 audience. As a result he recommended the use of less toxic therapies first and that patients be involved in the decision making. Not quite the guidance the audience perhaps hoped for.

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ASCO 2012: Zytiga fails to show overall survival pre-chemo

ASCO 2012 COU AA 302 Presentation Title Slide 300x225 ASCO 2012: Zytiga fails to show overall survival pre chemoMen with advanced prostate cancer want to know “if I take this drug, will I live longer?” Unfortunately, for abiraterone acetate (Zytiga®) in the pre-chemotherapy setting i.e for asymptomatic or mildly symptomatic men, doctors will only be able to say, “maybe” and tell the patient there is a strong trend towards an overall survival (OS) advantage.

You can read my Xconomy article published yesterday, on why I think it was a mistake for the abiraterone acetate COU-AA-302 trial (302 trial) in chemotherapy-naïve (pre-chemo) men to be stopped early.  The results were presented on Saturday at the American Society of Clinical Oncology (ASCO) meeting in Chicago.

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ASCO 2012: Having a meeting plan is key to success at #ASCO12

Chicago Wrigley Building 300x225 ASCO 2012: Having a meeting plan is key to success at #ASCO12This morning I am heading off to the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago from June 1 to 5, 2012.

Finalizing my conference schedule yesterday afternoon led me to reflect that at major meetings with multiple parallel sessions, one of the keys to success is having a plan before you arrive. 

ASCO 2012 Annual Meeting App Icon ASCO 2012: Having a meeting plan is key to success at #ASCO12This year, ASCO have the best Congress eplanner that I have yet to see, and what’s more you can not only create and print an online schedule or export it as an Excel spreadsheet, but sync it with your iPad or iPhone/Android conference app.

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ASCO 2012 Unofficial Tweetup

IMGP4940 300x225 ASCO 2012 Unofficial TweetupIt’s almost time to pack the comfortable shoes for the #blisterwalk (thank you @MaverickNY for that pithy description) across the bridge at ASCO 2012 in Chicago.

No matter what your ASCO program choices, attendees are destined like a modern day Sisyphus to walk the bridge repeatedly as your schedule takes you from one end of McCormick Place to the other.

I am looking forward to the new data expected at the meeting. For diehards who are at ASCO till the last day, next Tuesday will see Dr Chris Parker present updated data on the ALSYMPCA trial for radium-223 (Alpharadin) in advanced prostate cancer. We can expect to see an increase in overall survival (OS) from the 2.8 months presented in Stockholm last year. HT @BiotechStockRsr.

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Repetitive brain injury from high impact sports generates similar pathophysiology to traumatic brain injury in soldiers blown up by IEDs

Several retired American Football stars have ended up with chronic traumatic encephalophy (CTE), previously known as dementia pugilistica. It’s similar to Alzheimer’s disease in that the brain ends up with neurofibrillary tangles.

stm cover may16 Repetitive brain injury from high impact sports generates similar pathophysiology to traumatic brain injury in soldiers blown up by IEDs  CTE has also been seen in soldiers who have experienced blast induced traumatic brain injury (bTBI) from improvised explosive devices (IEDs). I previously wrote on this blog about how nanotechnology may revolutionize the detection of TBI using a nanomaterial that changes color.

Research published in the May 16, 2012 issue of Science Translational Magazine by Lee Goldstein and colleagues from the Molecular Aging and Development Laboratory at Boston University & other institutions, compared CTE neuropathology in blast-exposed military veterans and athletes with repetitive concussion injury.

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