Paris La Madeleine

How do we improve responses to checkpoint inhibitors in lung cancer?

The mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

March 26, 2015

Will CAR-T cells make an impact in solid tumours?

Novel targets are emerging in urothelial bladder cancer which may offer new therapeutic options for antibody and CAR-T cell therapy development.

March 25, 2015
Screen Shot 2015-03-24 at 5.26.55 AM

EAU 2015 Update on enzalutamide PREVAIL trial in advanced prostate cancer

Update in the PREVAIL trial in chemotherapy naive castrate resistant prostate cancer based on 765 deaths from the 2015 EAU conference in Madrid.

March 24, 2015
EAU 2015 Madrid Congress

Impact of TERRAIN trial on European Prostate Cancer treatment landscape #EAU15

The results of the TERRAIN prostate cancer clinical trial data were presented at the 2015 European Association of Urology (EAU) Congress in Madrid today.

March 24, 2015
Madrid Pescaderia

What would Charles Darwin make of renal cell carcinoma?

At the last count, the renal cell carcinoma (RCC) space is quite competitive with five VEGF inhibitors…

March 23, 2015
Dr Stephan Grupp CHOP

Sound Medicine Radio Hour Highlights Promise of CAR T Cell Immunotherapy

Listen to a short radio story on CAR T cell cancer immunotherapy produced for the Sound Medicine radio hour

March 22, 2015
WTC Memorial Liberty State Park

Cellular therapy with EBV-CTL reduces death post stem cell transplant

What is the potential of a new cell therapy with cytotoxic T lymphocytes against Epstein Barr Virus (EBV-CTL)?

March 20, 2015
Philadelphia Skyline

Emerging new biomarker for predicting checkpoint inhibitor responders

Predictive biomarkers of response will be key to reimbursement of immunotherapies in Europe. One is potentially emerging for ipilimumab (Yervoy), which may be useful in speeding up access.

March 19, 2015
Philadelphia Love

AACR 2015 Cancer Immunotherapy Preview

What are the emerging new trends in cancer immunotherapy? Beyond monotherapy lies many combination opportunities yet to be explored. At AACR in April, we will see a raft of novel approaches being discussed.

March 11, 2015

How to enhance checkpoint inhibitors in hematologic malignancies

Will checkpoint inhibitors make an impact in hematologic malignancies or will novel combinations be needed?

March 4, 2015
ASCO GU Orlando

How to make non-immunogenic cancers sensitive to checkpoint inhibitors

Not all cancers respond to checkpoint inhibitors - how can we change that situation? Here's one example, using prostate cancer as a model...

March 2, 2015
Birmingham Moor Street

ASCO GU 2015 Preview

What's hot at ASCU GU 2015? Focus on prostate and bladder cancers with checkpoint inhibitors and sequencing therapies

February 26, 2015
Dr Krishna Komanduri University of Miami

CAR-T and Gene Therapy excite BMT Tandem Meeting

Dr Krishna Komanduri discusses some of the best abstracts at the 2015 BMT Tandem meeting in San Diego.

February 25, 2015

Is AR-V7 a useful predictive biomarker in advanced prostate cancer

The ongoing story of the AR-V7 splice variant as a potential biomarker of response in mCRPC

February 23, 2015
Picton Library

Overcoming acquired resistance to EGFR therapies in colorectal cancer

Which new combinations could improve outcomes for colon cancer patients receiving EGFR therapies by overcoming acquired resistance?

February 19, 2015
Hastings Sea

Molecular Characterisation of Colorectal Cancer

We've seen very little real progress in colorectal cancer beyond incremental improvements since Erbitux and Avastin were approved a decade ago. Are we on the threshold of a new paradigm shift?

February 17, 2015
Sunset over Wirral

Overcoming acquired resistance to BRAF in colorectal cancer

Patients with BRAF driven colon cancer don't do as well as those with melanoma: how can we overcome acquired resistance to RAF treatment?

February 13, 2015
London Coffee Stand

CAR-T Cell Therapies from China are a Competitive Threat

Cellular Biomedicine Group (NASDAQ: CBMG) has acquired rights to the Chimeric Antigen Receptor T cell (CAR-T) therapy of the PLA General Hospital in Beijing.

February 11, 2015

The application of TILs, CARs and TCRs in cancer research

What does the evolving landscape for CAR, TIL and TCR cell therapies look like?

February 10, 2015
Rosenberg ASH Featured Image

Tumour infiltrating lymphocytes TILs: what are they and why do they matter?

The NCI have been at the forefront of developing novel cancer immunotherapies for several decades, but what is the current status of their groundbreaking work? Find out more in this primer on TILs.

February 5, 2015
Venetoclax GDC-0199 MOA

Will venetoclax impact in hematologic malignancies

ABT-199 is now known as venetoclax - has it overcome it's checkered history to get back on track?

February 4, 2015
Clovis JPM15 T790M Negative Data

Potential of Rociletinib in T790M negative NSCLC

Clovis have observed responses in T790M positive AND negative lung cancer with rociletinib - implications for the commercial opportunity are discussed in this post.

January 28, 2015
Sefton Park Man with Dog

Enzalutamide beats bicalutamide in advanced prostate cancer

The Phase 2 TERRAIN trial met its primary endpoint (PFS) with enzalutamide beating out bicalutamide in castrate resistant prostate cancer. What next?

January 22, 2015
ASCO GI 2015 San Francisco Fishermans Wharf

Precision medicine in advanced colorectal cancer

If we truly want to see a more precision medicine approach evolve then we have to first find the oncogenic drivers. At ASCO GI one study in particular caught my eye and attention, but you won’t find it written up in the medical lay press and it’s not that obvious unless you know what you’re looking for.

January 20, 2015
Iron Men of Crosby

Bellicum moves BPX-501 T Cell Therapy forward $BLCM

What's the vision for Bellicum Pharmaceuticals? In an in-depth interview CEO Tom Farrell and COO Annemarie Moseley discuss the benefits offered by their new products in development.

January 13, 2015
San Antonio Texas

Biomarin PARP inhibitor talazoparib shows promise in gBRCA Breast Cancer

Biomarin have a good shot on goal with their PARP inhibitor talazoparib in gBRCA breast cancer

January 9, 2015
Genetech Drug Development with Gene Antibody

Next generation approaches to immuno-oncology – where next?

What's next in immuno-oncology: what are potential ways to tackle the patients who do not respond to checkpoint immunotherapy?

January 8, 2015
Dr Julianne Smith Cellectis

Cellectis ramps up CAR-T development in 2015

What makes the Cellectis Chimeric Antigen Receptor CAR-T cell therapy different and what are the milestones expected in 2015?

January 6, 2015
Texas State Flag San Antonio

SABCS Update on Triple Negative Breast Cancer

In the last post of 2014, it’s time to address some pertinent questions on triple negative breast cancer (TNBC).

December 19, 2014
SABCS 2014 San Antonio Riverwalk

Do Checkpoint Inhibitors work in Triple Negative Breast Cancer?

There is a lot of interest in checkpoint inhibitors, do they look they will be effective in Triple Negative Breast Cancer?

December 10, 2014
Dungeness Crab San Francisco

ASH 2014 Day 3 Live blog #ASH14

"Manic Monday" at the annual meeting of the American Society of Hematology features multiple oral sessions run at the same time!

December 8, 2014
San Francisco Festive Cable Car

ASH 2014 Day 2 Live Blog #ASH14

Coverage of Day 2 of the annual meeting of the American Society of Hematology in San Francisco.

December 7, 2014
Historic Trolley Car San Francisco

ASH 2014 Day 1 Live Blog #ASH14

It's Day 1 of the 2014 annual meeting of the American Society of Hematology meeting in San Francisco.

December 6, 2014
San Francisco Cable Car Dec 2014

Top 10 AML abstracts at ASH 2014

There are a lot of new products in development for AML. Here's my top 10 abstracts to watch out for at ASH 2014 in San Francisco.

December 4, 2014
ASH 2014 San Francisco

ASH 2014 Hodgkins Lymphoma and DLBCL Preview

Preview of ASH 2014 Key Abstracts in Lymphomas including HL and aggressive DLBCL

December 3, 2014
San Francisco Coit Tower

ASH 2014 Annual Meeting Multiple Myeloma Preview

ASH 2014 Multiple Myeloma data looks like it offers much promise for new treatments as well as an increasingly competitive marketplace

December 2, 2014
Nature Letter PDL1 Roy Herbst

The Science of PD1 PDL1 Cancer Immunotherapy

The science of targeting PD-1 and it's ligand PD-L1 in cancer immunotherapy is highlighted in five Letters published in Nature this week.

November 26, 2014
Maverick Canal Barge

EORTC Molecular Targets – new developments in Ovarian Cancer

Ovarian cancer has lagged behind other solid tumours in terms of development, but this situation may soon change with promising new agents being developed

November 19, 2014

Rociletinib versus AZD9291 race to market heats up in T790M lung cancer at EORTC

Clovis present their Phase 2 data with the new rociletinib formulation at EORTC-AACR-NCI in Barcelona

November 19, 2014
Chocolate Rabbits

Agios IDH1 Inhibitor AG-120 shows promise in AML $AGIO

Agios AG-120 IDH1 Inhibitor shows promise in acute myeloid leukemia (AML) according to data to be presented at the EORTC-AACR-NCI Molecular Targets and Cancer Therapeutics Symposium in Barcelona

November 18, 2014
Hy Levitsky Roche SITC 2014

Targeting CD40 in Cancer Immunotherapy

How can we jumpstart the immune system to enable more patients to respond? At SITC we learned more about targeting CD40 to achieve this.

November 20, 2014
Fall Colors National Harbor MD

Can you reduce Graft versus Host Disease GvHD by regulating gut bacteria?

At the SITC 2014 annual meeting, Dr van den Brink presented data on how the bacteria in our gut (the intestinal microbiome) can impact GvHD.

November 18, 2014
SITC 2014 Entrance

Challenge of Cytokine Release Syndrome in CD19 CAR-T Cell Therapy

At the Society for Immunotherapy of Cancer (SITC) meeting last week, one of the Hot Topic sessions that took place after the conference formally ended was in managing the toxicities associated with chimeric antigen receptor T cell (CAR-T) therapy.

November 17, 2014
SITC 2014 Oral Poster Session

Will combining anti-OX40 with a checkpoint inhibitor matter in cancer?

OX40 could be an exciting new target in immune-oncology that could be combined with checkpoint inhibitors to improve the T cell response.

November 11, 2014
SITC 2014 National Harbor MD Fall Colors

SITC 2014 Cancer Immunotherapy Day 1

Reflections on Day 1 of the 2014 annual meeting of the Society for Immunotherapy of Cancer (SITC).

November 8, 2014
National Harbor Maryland

SITC 2014 Cancer Immunotherapy Workshop Review

Day 1 of the SITC annual meeting started with two workshops on immunotherapy and combination therapy

November 7, 2014
Washington DC in Fall

SITC 2014 Cancer Immunotherapy Annual Meeting Preview

This week sees the start of the 2014 annual meeting of the Society for Immunotherapy of Cancer (SITC) at National Harbor, MD. We’re excited to be attending this meeting for the first time.

November 4, 2014
ESMO 2014 Posters

Immuno-Oncology Gems in the ESMO Poster Halls

There was a lot going on in lung, melanoma, renal and colorectal cancer in terms of immunotherapy in Madrid.

November 3, 2014
ESMO Entrance Hall

Update on PD1 checkpoint inhibition in lung cancer

Merck announced their Breakthrough therapy designation for Keytruda in lung cancer this morning. What did we learn from the updated data for checkpoint inhibitors in NSCLC at ESMO that was different from ASCO?

October 27, 2014
ESMO 2014 Audience

New therapies are emerging for the treatment of advanced stomach cancer

Checkpoint inhibitors are looking very promising in advanced gastric cancer

October 23, 2014
ESMO 2014 Bladder Cancer

Breathing New Life into Bladder Cancer Treatment

At ESMO 2014, phase 1 clinical trial data in bladder cancer was presented for Pembrolizumab (Merck) and MPDL3280A (Roche/Genentech).

October 22, 2014
Roche Media Briefing ESMO 2014

Potential of IDO as Immunotherapy Target

Genentech and NewLink announced a deal to license an IDO inhibitor. What's the impact of this on the IO pipeline?

October 20, 2014
ESMO Poster Viewing

ESMO Posters Highlight New Cancer Drugs in Development

Posters on new cancer drugs in development with novel targets were presented at ESMO 2014 Congress in Madrid.

October 15, 2014
ESMO 2014 CRC Symposium

New drug targets may change Colorectal Cancer Landscape

Advances in Metastatic Colorectal Cancer may come from new druggable targets according to ESMO 2014 CRC Symposium

October 13, 2014
ESMO 2014 Madrid Audience

ESMO 2014: Update on the ALK lung cancer market

How is the ALK+ lung cancer market developing now that there are multiple next generation competitors following on from Xalkori and Zykadia? Check out our analysis of the developing landscape...

October 9, 2014
ESMO 2014 Dr Taplin Galeterone ARMOR2 Presentation

Did Galeterone ARMOR2 Prostate Cancer Data Impress at ESMO 2014?

At ESMO 2014 Mary-Ellen Taplin, MD (Dana-Farber Cancer Institute) presented the results of the Tokai Pharmaceuticals ARMOR2 clinical trial of galeterone in men with advanced prostate cancer.

October 3, 2014
ESMO 2014 E Posters

ESMO 2014 Cancer Congress Day 3 Live Blog

Day 3 of the live blog from the ESMO 2014 Cancer Congress in Madrid.

September 28, 2014
ESMO 2014 Congress Madrid

ESMO 2014 Live Blog Day 2 #ESMO14

Day 2 Live Blog with news and commentary on what's taking place at the ESMO Cancer Congress in Madrid

September 28, 2014
Roche Promise of Immunotherapy Quote

ESMO 2014 Cancer Congress Day 1 Live Blog

ESMO 2014 Cancer Congress data starts to roll out today - throughout the day we'll be updating the blog with initial impressions of data as it's presented.

September 27, 2014
Air France Concorde Paris CDG

ESMO 2014 Takes Off with Release of Oral Abstracts #ESMO14

Most of the abstracts for oral presentations at the forthcoming ESMO cancer congress in Madrid have just been released. This is a preview of some that caught my attention.

September 24, 2014
Do not feed the Pelicans

ESMO 2014 Scientific Symposia Preview

There are some interesting science symposia at #ESMO14 in both immunotherapy and targeted therapies. We review what the hot topics are here.

September 19, 2014
St Pancras International

ESMO 2014 Poster Preview

A review of the key poster and poster discussion abstracts on immunotherapy and targeted therapies at ESMO 2014

September 18, 2014
Tall Ship Pageant

ESMO 2014 Preview: Immuno-oncology

Update on what to watch out for in immunotherapy at ESMO 2014.

September 16, 2014
Tall Ships colour

ESMO 2014 Preview on Breast Cancer

Preview of some important breast cancer trials being presented in Madrid at #ESMO14.

September 10, 2014
Deckchairs Regents Park

What’s hot in Melanoma at ESMO 2014 Cancer Congress? #ESMO14

With the recent FDA approval of Pembrolizumab (Keytruda) we can expect melanoma to be a hot topic at ESMO 2014.

September 5, 2014
London Changing Guard

What’s hot in prostate cancer at ESMO 2014? #ESMO14

Preview of Prostate Cancer oral presentations at ESMO 2014 Cancer Congress in Madrid.

September 2, 2014
Shard London Waterfront

ESMO 2014 Congress Plenary Preview #ESMO14

Review of the preliminary programme and late breakers in the Presidential Symposia at ESMO 2014.

August 28, 2014
ESMO 2014 Access Restriction

ESMO 2014 Cancer Congress bans Press, Nurses and Patient Advocates from Exhibits and Symposia #ESMO14

Restricting the freedom of the press and creating a two-tier access to information at major medical meetings such as ESMO 2014 is both pernicious and toxic.

August 25, 2014
ESMO 2014 Madrid

ESMO 2014 Madrid Congress Preview #ESMO14

2014 Congress of the European Society for Medical Oncology (ESMO) is set to take place this year in Madrid from September 26 to 30th.

August 22, 2014
ASCO 2014 Response Rate Schwarz Discussant

Beyond Response and Progression in Cancer Clinical Trials

To get more cancer therapies to the right patients faster, we need to find better surrogate markers or biomarkers of response that are inextricably linked to survival.

August 20, 2014
Hastings Fishing Boat

Carfilzomib fails in refractory myeloma FOCUS trial

Amgen's phase III FOCUS trial of carfilzomib (Kyprolis) in relapsed/refractory multiple myeloma failed to meet its primary endpoint of overall survival.

August 14, 2014
Pirate Flag

Update on potential of Galeterone in Prostate Cancer $TKAI

Tokai Pharmaceuticals ($TKAI) have filed plans for a $75M IPO, largely based on the potential of their phase 2 prostate cancer compound, galeterone. What is the prostate cancer market opportunity for $TKAI?

August 13, 2014
ASCO Chicago 2014 MM

Impact of Kyprolis ASPIRE Trial on Multiple Myeloma Market

Amgen announced the results of the phase III ASPIRE clinical trial for Kyprolis. What impact will this data have on the multiple myeloma landscape?

August 6, 2014
Stand out from Crowd

Which therapies will stand out in the CLL market?

New CLL therapies that stand out in a rapidly changing CLL landscape include obinutuzumab (Gazyva), ibrutinib (Imbruvica) idelalisib (Zydelig), ABT-199/GDC-0199 and CTL019.

July 30, 2014
Antoni Ribas ASCO 2014 Melanoma

What impact will nivolumab & pembrolizumab have on advanced melanoma?

How will we decide which therapies to give patients with metastatic melanoma once the new immunotherapies are available?

July 23, 2014
Another Place

ASCO 2014 Update on the AML landscape

There are a number of new targets, therapies and approaches in AML being investigated but which ones look most promising in this challenging landscape?

July 17, 2014
ABT-199 single agent in R/R CLL from ASCO 2014 Abstract 7015 Source: Roche

ASCO 2014 Will ABT-199 change the CLL landscape?

After a few setbacks in clinical development, some solid data is emerging with AbbVie/Genentech's ABT-199/GDC-0199 in CLL. Some more mature data at ASCO was very encouraging...

July 14, 2014
ASCO 2014 Chicago Contemplation

ASCO 2014 New horizons in DLBCL and aggressive lymphomas

Diffuse large B cell lymphomas (DLBCL) are an aggressive subset of non-Hodgkins lymphomas that generally have a poor prognosis and a high unmet medical need. There is a raft of promising new therapies being evaluated for treatment.

July 9, 2014
Cellectis CSO CEO

Can Cellectis Revolutionize CAR-T cell immunotherapy?

Cellectis is a Paris based biotechnology company with a “blue ocean” strategy that, if successful, could revolutionize cancer immunotherapy.

July 7, 2014
ASCO 2014 The Bean Chicago

ASCO 2014 blinatumomab in B cell ALL

Initial phase 2 data for Amgen's blinatumomab in B cell ALL looked encouraging 2 years ago but has it held up over time?

July 1, 2014
ASCO 2014 Meeting Logo

ASCO 2014 Diffuse Large B Cell Lymphoma DLBCL Progress

Several new agents in development emerged for the treatment of aggressive NHL (DLBCL and FL), including SGN-CD19A, polatuzumab vedotin and pinatuzumab vedotin.

June 30, 2014
ASCO 2014 General Poster Hall

ASCO 2014 Gems from Poster Hall part 2

A review of poster data at ASCO 2014 for new drugs from new cancer drugs from $CLDX, $OMED & NuCana BioMed.

June 27, 2014
ASCO 2014 Poster Hall

Gems from the ASCO 2014 Poster Hall – Part 1

Selection of some of the many posters that caught our attention. Companies whose products are mentioned include: $EXEL, $RHHBY, $XLRN, $MRK

June 24, 2014
Kite Pharma Banner

Kite Pharma Challenges and Opportunities Post-IPO $KITE

After it's successful IPO, what are some of the challenges and opportunities facing Kite Pharma and their CAR-T cell immunotherapy?

June 23, 2014
ASCO 2014 Crowds

AstraZeneca MEDI4736 shows Immuno-Oncology promise at ASCO 2014

AstraZeneca showed impressive data at ASCO 2014 for MEDI4736, a new anti PD-L1 immunotherapy.

June 19, 2014
Chicago Board of Trade Building

Making a difference in advanced bladder cancer

There have been no new therapies in urothelial bladder cancer for 30 years - until now...

June 17, 2014
Chicago Art Institute

ASCO 2014 Nivolumab vs Pembrolizumab in Metastatic Melanoma

PD-1 antibodies nivolumab and pembrolizumab show considerable promise in metastatic melanoma. At ASCO 2014 we learnt more about how they compare against each other and their potential as a backbone for combinations.

June 16, 2014
ASCO 2014 Chicago the Bean

Combination strategies for nivolumab in Renal Cell Carcinoma

What does the ASCO 2014 data show when you combine checkpoint inhibitors nivolumab and ipilimumab?

June 13, 2014
ASCO 2014 Poster Hall

ASCO 2014 What do oncologists think of PARP inhibitors?

With the intense focus on immino-oncology, are targeted agents passe now?

June 11, 2014
View of downtown Chicago

A potential new target for prostate cancer drug development

A predictive biomarker for resistance to treatment by enzalutamide and abiraterone may lead to new prostate cancer drug development opportunities.

June 9, 2014
Clovis CO-1686 ASCO 2014

Why Clovis CO-1686 was not an ASCO 2014 loser

Clovis Oncology CO-1686 is in competition with AstraZeneca's AZD9291, but was it really a "loser" at ASCO 2014 as many think it was?

June 6, 2014
ASCO 2014 Arie Crown

ASCO 2014 Day 5 Live Blog #ASCO14

Final day at ASCO 2014 - what are the diehards listening to this morning?

June 3, 2014
Bertrand Tombal ASCO 2014

ASCO 2014 Annual Meeting Live Blog Day 4 #ASCO14

Live blog with commentary on Day 4 of the ASCO 2014 annual meeting in Chicago.

June 2, 2014
ASCO 2014 Poster Hall

ASCO 2014 Meeting Day 3 Live Blog #ASCO14

Live blog with updates from Day 3 at ASCO 2014

June 1, 2014
View of Chicago

ASCO 2014 Day 2 Live Blog #ASCO14

Live Blog from Day 2 of ASCO 2014 in Chicago.

May 31, 2014
ASCO 2014 View of Lake Michigan

ASCO 2014 Chicago Day 1 Blog #ASCO14

Coverage of day 1 at ASCO 2014 with commentary on some of the poster highlights.

May 30, 2014
ASCO 2011 #BlisterWalk

ASCO 2014 CLL and iNHL Preview #ASCO14

Update on the top drugs in CLL including ibrutinib, obinutuzumab, idelalisib, ABT-199, GS-9973, ONO-4059, CTL019, TAK659, IPI-145, cerdulatinib and others.

May 28, 2014
Panobinostat, a deacteylase inhibitor from Novartis

ASCO 2014 Multiple Myeloma Preview #ASCO14

Highlights in multiple myeloma at ASCO include drugs with a different mechanism of action eg panobinostat, daratumumab and elotuzumab, #ASCO14

May 27, 2014
PREVAIL trial design - With permission from Medivation and Astellas

Insights on the enzalutamide PREVAIL data pre-chemotherapy in advanced prostate cancer

Medivation and Astellas provided an update at AUA 2014 on the Xtandi PREVAIL data with a breakdown for visceral and non-visceral disease.

May 19, 2014
Orlando AUA 2014

AUA 2014 – New targets in prostate cancer

New targets are emerging in advanced prostate cancer that may help improve outcomes and overcome adaptive resistance

May 18, 2014
View of Chicago and the Bean

ASCO 2014 Preview #1: When triple combinations make sense

How we could overcome resistance to BRAF inhibitors in colon cancer with a triple combination approach

May 15, 2014
Source: Dr K Flaherty

Bench to bedside and back again with BRAF and NRAS mutant cancers

Can we improve responses to Zelboraf in advanced melanoma? The answer is a startling yes.

May 6, 2014
T cell immunotherapy

6 important things I learned from AACR 2014 on immuno-oncology

Insights on checkpoint inhibitors, co-stimulants, CAR T cell therapy and bispecific antibody TCRs

May 2, 2014
AACR San Diego

New directions in immuno-oncology in biomarkers and combinations

Update on emerging potential immuno-oncology biomarkers and combinations from AACR

April 30, 2014
PSA Changes with ODM-201 courtesy of Orion Pharma

AACR 2014: Review of novel targeted approaches in lung and prostate cancers

Overcoming acquired resistance to therapy is a major focus in lung and prostate cancers. Check out the new developments from AACR.

April 22, 2014
IDH2 and the Krebs cycle Source: Yang et al., 2012

Promising new targeted cancer agents emerge at AACR 2014

Exciting new data was seen at AACR this year, including a novel ADC with a new target in melanoma, a metabolic target and understanding adaptive resistance to PI3K in breast cancer.

April 17, 2014
Source: Qiagen

Next generation FGFR inhibitors are early but promising in selected cancers

After disappointing results from FGFR inhibitors brivanib and dovitinib, can the next generation compounds overcome scepticism and offer better efficacy?

April 16, 2014
immune checkpoints

Insights from AACR on immunotherapy and checkpoint inhibitors

Immunotherapy is coming of age despite the chequered history in the past with vaccines. In part 1 we explore the state of play in lung cancer.

April 15, 2014
Rick Young at AACR 2014

Super Enhancers – what are they and why do they matter in cancer research?

Understanding the regulatory circuitry that controls cell state and differentiation may turn out to be groundbreaking research that changes the way we think about targeting and treating cancer.

April 14, 2014
sunrise over san diego

Pfizer’s palbociclib data in ER+ breast cancer – hit or miss?

Pfizer's palbociclib showed promising survival data at the AACR annual meeting this weekend, but is it enough to garner approval on the basis of the phase II data?

April 8, 2014
MSKCC Trial Suspensions

The real story behind Juno’s CAR T cell therapy suspensions

This weekend at AACR a controversy emerged on the safety of Juno's CAR T cell therapy.

April 6, 2014
Screenshot 2014-04-02 13.29.39

Innate immunotherapy – is it ready for prime time in cancer research?

A review of innate immunotherapies including CD47, KIR, MICA and anti-glucan data at AACR in San Diego.

April 2, 2014

Novel targets and approaches in triple negative breast cancer

What are the new targets and drug combinations that are emerging in triple negative breast cancer (TNBC)? find out more about the promising developments in this field.

April 1, 2014
Clovis Oncology CO-1686 ELCC 2014

AACR 2014 Preview: Novel targets and approaches

Review of some interesting cancer pipeline drugs at AACR 2014 including TKIs and ADC therapies.

March 27, 2014
mtor pathway

What can we learn from exceptional responders in cancer trials?

Following on from yesterday’s post on the potential for small basket trials in ER+ breast cancer with…

March 26, 2014
Source: Nature

Do ESR1 mutations drive endocrine resistance during the progression of ER+ breast cancer?

Today brings the launch of our series on the AACR annual meeting Previews.  A variety of different…

March 25, 2014
AACR MT Boston

Update on overcoming resistance in metastatic melanoma

What new clinical approaches are being investigated to overcome resistance in melanoma?

March 20, 2014
CDK4/6 inhibition - Source: Lilly

CDK inhibitors: will palbociclib and LEE011 make it to market in breast cancer?

Cell cycle inhibitors have been shown to have utility in cancer treatment. A new subclass is emerging to target CDK4/6 with more specificity and less toxicity.

March 19, 2014
ISPY2 trial plan

On neratinib in neoadjuvant breast cancer

Puma Biotech are expected to present the neoadjuvant data from ISPY2 for their pan HER inhibitor, neratinib, so what's the deal?

March 14, 2014
south pointe

MBCC: Will NGS change the way we treat metastatic breast cancer?

Dr Debu Tripathy presented one of the highlights of the MBCC conference - how we can use genomics to improve clinical trials in TNBC and MBC.

March 13, 2014

MBCC: Changing the way we approach advanced breast cancer

Can therapy for advanced breast cancer be individualized using proteomics and genomics data?

March 12, 2014
Be Clear on Cancer Ovarian Cancer Awareness Liverpool March 8, 2014

Luciana Berger MP supports ovarian cancer awareness in Liverpool

England lags behind other European countries in survival rates for ovarian cancer. In a recent interview at St John's Shopping Center in Liverpool, the Shadow Minister for Public Health, Luciana Berger MP talks about the importance of raising cancer awareness.

March 10, 2014
Source: James Kochendefer, NCI

Will CAR T cells give new therapies for NHL and CLL a run for their money?

Much has been written about CAR T cells in B cell leukemias, but what about B cell lymphomas? Kite and the NCI had the honour of being the first to present data from ASH on their therapy in refractory DLBCL lymphomas

March 6, 2014
MET Pathway

MetMab fails in phase III advanced lung cancer trial

Nearly 4 years on from the original phase 2 data at ESMO, and we learn that MetMab (onartuzumab) did not meet it's endpoint in the interim analysis of lung cancer patients with MET expression.

March 3, 2014
Logo of American Society of Hematology

ASH 2013: Is carfilzomib associated with increased cardiovascular events?

There has been much debate about the cardiovascular risks associated with proteasome inhibitors in multiple myeloma, but what does the data show? A synopsis of the ASH 2013 data and what we can learn in the future...

February 14, 2014
Bertrand Tombal ASCO GU 2013

ASCO GU 2014: Will there be a market for Medivation’s enzalutamide in M0 prostate cancer?

The new race to market in advanced prostate cancer is in the M0 asymptomatic space. Several AR antagonists are competing to run trials here but will they lead to men living longer or not?

February 10, 2014
Anti-CTLA-4 ipilimumab

Update on immuno-oncology and biomarkers of response

ASCO GU saw an update on the ipilimumab study in post chemotherapy CRPC. New biomarker data published this week in melanoma may be potentially useful in prostate and other tumour types.

February 5, 2014
Screenshot 2014-02-04 15.14.55

ASCO GU 2014 Optimal targeting of anti PD-1 and PD-L1 therapies in renal cancer

Update on progress with anti-PD1 and PD-L1 immunotherapies in renal cell cancer. Where is the field going in this space?

February 4, 2014
Andrew Armstrong ASCO GU Title Slide

ASCO GU 2014 Beyond Enzalutamide and Abiraterone – What’s Next?

Cross resistance between enzalutamide and abiraterone means that new prostate cancer drugs and targets are needed.

January 31, 2014
San Francisco Coit Tower

ASCO GU 2014: Will Galeterone make it to market in Prostate Cancer?

At ASCO GU 2014 Tokai Pharmaceuticals report data for the ARMOR2 trial with reformulated galeterone (TOK-001) in men with prostate cancer. Is this drug likely to make it to market?

January 30, 2014

ASCO GU Interview with Dr Tom Beer on Medivation PREVAIL trial data

Enzalutamide significantly decreases the risk of death and delays progression in the PREVAIL trial

January 28, 2014
San Francisco Embarcadero

ASCO GU 2014: Why does the Medivation PREVAIL trial matter?

At ASCO GU this week, the clinical data will be presented for the Medivation/Astellas PREVAIL phase III clinical trial of enzalutamide (Xtandi) in men with advanced prostate cancer prior to chemotherapy. The results of this trial not only have important commercial implications for Medivation/Astellas but for competitors in the prostate cancer market.

January 27, 2014
Source: Roche

Update on anti-PD-L1 cancer immunotherapy

Roche Genentech are developing their anti-PD-L1 as both monotherapy and also in combination with targeted therapies in lung, melanoma, renal and colon cancers. How is the early development progressing?

January 22, 2014
Title Slide ASCO GI Keynote

ASCO GI Keynote: The future of Immunotherapy is Combinations

“We are at beginning of a REVOLUTION in immunotherapy,” said Elizabeth M. Jaffee, MD at the start of American Society of Clinical Oncology GastroIntestinal (ASCO GI) symposium keynote lecture on Immunologic Treatments for GI Cancers.

January 21, 2014
Clovis Oncology JPM 2014

Update on CO-1686 and AZD9291 race to market in T790M NSCLC

Update from JP Morgan Healthcare 2014 on Clovis Oncology and AstraZeneca race to market with new drugs for treatment of T790M positive non-small cell lung cancer.

January 15, 2014

Can Agios score a winner with their anti-cancer metabolism molecules?

Agios Pharmaceuticals is focused on developing new therapies that target mutations in cancer metabolism, including IDH 1 and 2 for AML and Glioblastoma. Will they be successful despite the huge complexity involved in the underlying processes?

January 13, 2014
CAR T Cells

ASH 2013 Stunning ALL data with Novartis CTL019 CAR Therapy

UPenn and CHOP are using genetically modified chimeric antigen receptor (CAR) T cells to treat patients with B cell cancers such as ALL, B cell NHL, CLL and other B cell malignancies. At ASH, the impressive data from adult and pediatric ALL was presented. This post includes insights on this approach and an interview with Dr Stephan Grupp on the pediatric data.

January 9, 2014
Foundation Medicine ASH 2013

Insights on Foundation Medicine and how molecular testing will transform cancer research

Increasingly, we are seeing the evolution of diagnostic tests in cancer research. Foundation Medicine are using their gene sequencing platform to identify actionable mutations and assist oncologists make better treatment decisions for their patients.

January 8, 2014
Screen Shot 2014-01-07 at 11.22.26 AM

New Immunotherapy data at IASLC Lung Cancer Meeting

Immunotherapy continues to be a hot topic in oncology with anti-PD-1 and other new approaches being discussed at the AACR-IASLC meeting in San Diego

January 7, 2014
EXEL Share Price Jan 6 2014

Will Exelixis Cabozantinib COMET-1 prostate cancer trial be positive?

The share price of Exelixis ($EXEL) is starting a run-up (after months in the doldrums) in advance of anticipated results from the COMET-1 phase 3 trial in metastatic castrate resistant prostate cancer (mCRPC) for cabozantinib (Cometriq, formerly XL184). Cabozantinib has been shown to significantly improve bone scans and decrease pain, but will it show an improvement in OS?

January 6, 2014
San Francisco ASCO GI Cancer Symposium 2013

ASCO GI 2014 Preview: Pancreatic and Gastric Cancer

Preview of some of the key data being presented at ASCO GI in San Francisco this month.

January 3, 2014
San Francisco Golden Gate Bridge

ASCO GU 2014 Prostate Cancer Preview #GU14

ASCO GU symposium takes place at the San Francisco Marriott Marquis from Jan 20 – February 1, 2014. This preview discusses data to be presented on enzalutamide (Xtandi), abiraterone (Zytiga), ODM-201, ARN-509, ipilimumab (Yervoy).

December 30, 2013
ASH 2013 Poster Hall

ASH 2013 – gems from the poster halls

There are some 5,000 abstarcts at ASH, many of them posters - what were the interesting nuggets this year?

December 18, 2013
BCR Signaling

ASH 2013: New BTK Inhibitor ONO-4059 shows early promise in CLL – is it a future competitor to ibrutinib?

BTK inhibition in the B cell receptor (BCR) pathway has been an exciting area of development over the last couple of years. What do the new competitors entering this space look like?

December 17, 2013

Winners and Losers in CLL at American Society of Hematology

There was a wealth of new data in CLL at ASH but which companies or drugs were the winners and losers in New Orleans? Find out...

December 16, 2013
Renier Brentjens ASH 2013 Disclosure

Juno Therapeutics takes on Novartis and seeks to revolutionize the treatment of blood cancers – an interview with Renier Brentjens

Juno Therapeutics is a start-up company with a mission to revolutionize the treatment of blood cancers through the use of chimeric antigen receptor (CAR) modified T cell therapy. The company recently launched with $120 million of series A funding. One of the scientific founders is Renier Brentjens MD, PhD, the Director of Cell Therapeutics at the Memorial Sloan-Kettering Cancer Center in NYC. He kindly gave an interview while at the ASH annual meeting in New Orleans.

December 13, 2013
The Alamo San Antonio

AbbVie’s PARP inhibitor veliparib is highly active in triple negative breast cancer

The first readout from the I-SPY2 neoadjuvant breast cancer trial comes from the veliparib (PARP) arm.

December 13, 2013
KIR Occupancy by IPH2101

Will anti-KIR immunotherapy make an impact in hematologic malignancies?

Immuno-oncology is a hot topic at the moment and many new targets are emerging that may be useful in combination. This post discusses Innate Pharma's anti-KIR program in hematologic malignancies.

December 12, 2013
San Antonio River Walk

What to watch for at San Antonio Breast Cancer Symposium

A preview of some of the landmark trial data emerging from the 2013 San Antonio Breast Cancer Symposium

December 11, 2013
ASH 2013 Annual Meeting

ASH 2013 Novel Treatments for CLL – notes from the road

One of the most interesting oral sessions at ASH 2013 took place on the last day and featured data on novel treatments for CLL. Data was presented on ABT-199, dinaciclib and the CAR-modified T-cell therapies in development by Novartis & Juno Therapeutics.

December 11, 2013
ASH 2013 Lymphoma Session

ASH 2013 Novel Agents in Lymphoma – notes from the road

At ASH 2013 data on novel agents for the treatment of lymphoma was presented. This post discusses data for idelalisib in iNHL, SAR245409 in R/R Follicular Lymphoma and BAY-BAY 80-6946 (copanlisib).

December 9, 2013
Prof John Seymour ASH 2013

ASH 2013 ABT-199 CLL TLS Death blamed on Failure to Follow Protocol

In the ASH 2013 media briefing on CLL, Prof John Seymour answered questions about ABT-199 CLL clinical trial deaths due to tumor lysis syndrome

December 8, 2013
ASH 2013 Letai

ASH 2013 BH3 profiling identifies new targets for Bcl-2 inhibitors

ABT-199 has activity in CLL, but what about other tumor types? Check out this post to find out about a new target with potential.

December 8, 2013
NVS Panobinostat

Panobinostat may change Multiple Myeloma Competitive Landscape

Novartis announced this morning that their novel pan-HDAC inhibitor, panobinostat (LBH589) in combination with bortezomib (Velcade) and dexamethasone significantly prolonged progression-free survival (PFS) of patients with Multiple Myeloma in the phase III PANORAMA-1 trial.

December 6, 2013
ASH 2013 Susan O'Brien CLL CME

ASH 2013 New Horizons in CLL – notes from the road

With many new therapies emerging for the treatment of CLL, what criteria can physicians use to decide which therapy to give a patient?

December 7, 2013
ASH Seattle Genetics Balloons

ASH 2013 Preview: quick note on non-Hodgkin’s and Hodgkin’s lymphomas

Will the B cell signaling drugs work in NHL as well as CLL? What of Adcetris in front-line HL?

December 6, 2013
Brentjens CART Slide

ASH 2013 Preview: will new Seattle startup Juno Therapeutics push Novartis and U Penn in CART?

Chimeric Antigen Receptor T cell technology (CART) is an exciting new area, especially in hematologic malignancies. With the formation of a new start-up in Seattle, Juno Therapeutics, things just got very interesting...

December 4, 2013
Sunset Miami Beach

ASH 2013 Preview – Chronic Lymphocytic Leukemia (CLL)

A review of the upcoming CLL data from the American Society of Hematology ASH meeting.

December 2, 2013
myeloid cells, Source: Wikipedia

ASH 2013 Multiple Myeloma Preview

Comprehensive preview of the new developments in multiple myeloma from ASH 2013.

November 25, 2013
Fall NYC Central Park

FDA Breakthrough Therapy Designation Benefits – part 2 of an interview with John Jenkins

FDA Office of New Drugs Director John Jenkins discusses the benefits of the Breakthrough Therapy designation and some of the challenges the agency faces in administering it.

November 26, 2013
Washington DC Fall Colors

Understanding the Breakthrough Therapy Designation – Part 1 of an interview with FDA New Drugs Director John Jenkins

John K. Jenkins, MD, Director of the Office of New Drugs, Center for Drug Evaluation and Research at the FDA offers a senior management perspective on what is a breakthrough?

November 15, 2013
ASH 2012 Atlanta meeting

ASH 2013 Myelofibrosis Preview

A lot of companies are presenting myelofibrosis data at this year's ASH annual meeting in New Orleans. This preview discusses abstracts for ruxolitinib, INCB039110, momelotinib, fedratinib, BMS-91143, pacritinib, LY2784544, pomalidomide, sonidegib.

November 11, 2013
aacr molecular targets boston 2013

The future of cancer research – Part 2

The huge wealth of research at the AACR-NCI-EORTC Boston conference provided a great learning environment of where future research with TKIs is likely to be heading...

November 6, 2013
Iwakuni Bridge

The future of cancer research – what I learned from the AACR Targets meeting Part 1

The cancer landscape is rapidly changing, in more ways than people realise. Diagnostics are also of increasing importance in helping to decide which therapies patients should receive to optimize treatment.

November 5, 2013
Dr Deepak Sampath, Genentech

Gazyva and ABT-199 in CLL & NHL – an interview with Genentech’s Deepak Sampath

An interview with Dr Deepak Sampath from Genentech on the rational for combining obinutuzumab (GA101) with GDC-0199 (ABT-199) for the treatment of B-cell hematological malignancies such as CLL & non Hodgkin’s lymphoma (NHL).

November 1, 2013
Sydney Opera House Harbor Bridge

AstraZeneca leaps over Clovis with AZD9291 data at World Lung Conference

Data presented at the World Lung Cancer conference in Sydney suggests AstraZeneca AZD9291 is now ahead of Clovis Oncology CO-1686 in the race to bring a third-generation epidermal growth factor receptor (EGFR) inhibitor to market that targets the T790M resistance mutation.

October 30, 2013
Fall Colors Boston

New insights on checkpoint inhibitors and CART in CLL and solid tumors

An update on checkpoint inhibitors and CART from the AACR-NCI-EORTC Molecular Targets meeting - a lot of exciting possibilities are emerging!

October 25, 2013
Fall Boston Colors

Abraxane kills potential of MLN0264 in pancreatic cancer

Following the FDA approval of Abraxane, MLN0264, a novel ADC targeting GCC, may no longer have potential as a therapeutic in pancreatic cancer.

October 21, 2013
Boston Prudential Center

Cerulean CRLX101 Challenges and Opportunities

Cerulean are developing a novel nanopharmaceutical that targets HIF1-alpha and is synergistic with anti-angiogenic drugs for RCC and Ovarian cancers.

October 21, 2013
Charles River Boston October 2013

AstraZeneca ramps up AZD9291 lung cancer clinical development

At the AACR-EORTC-NCI Molecular Targets and Cancer Therapeutics conference, Susan Galbraith, M.D, Ph.D. Head of the Oncology Innovative Medicines Unit at AstraZeneca discussed the rapid development of AZD9291, a potent and selective third-generation EGFR inhibitor.

October 20, 2013
Boston Charles River October 2013

Pfizer next gen ALK inhibitor PF-06463922 could replace Xalkori

Preclinical data for PF-06463922 (Pfizer), a next generation ALK inhibitor, with potency for all known Crizotinib ALK resistant mutants and ability to cross the blood brain barrier was presented today at the 2013 International Conference on Molecular Targets and Cancer Therapeutics in Boston.

October 20, 2013
MIT Koch

A quick preview of the AACR Molecular Targets Conference

Preview of some of the interesting non-embargoed abstracts from the ACCR-NCI-EORTC Molecular Targets conference in Boston

October 15, 2013
Back Bay Boston

Preview of 2013 AACR Molecular Targets Conference in Boston

Preview of 2013 AACR-EORTC-NCI Molecular Targets and Cancer Therapeutics Conference in Boston. This is a "must attend" meeting for anyone interested in cancer drug development.

October 11, 2013

ECCO Day 3: Update on alectinib, PD-L1, PI3K and MEK

Update on ALK (alectinib), PD-L1 (MEDI4736), PI3K (GDC-0980 and BKM120) and MEK (trametinib) inhibitors in solid tumours

September 30, 2013
ECCO 2013 Poster Hall

Dr Oliver Sartor shares his thoughts on Prostate Cancer data at ECCO 2013

Dr Oliver Sartor, one of the leading experts in Prostate Cancer shares his thoughts on the prostate cancer data presented at ECCO 2013.

September 30, 2013
ECCO 2013 Bikes

ECCO 2013: AZD9291 shows early promise in T790M NSCLC

Promising preliminary phase 1 data for AstraZeneca’s AZD9291 in T790M+ NSCLC presented today at the European Cancer Congress (ECCO 2013) is good news for lung cancer patients.

September 29, 2013
BMN 673 waterfall plot in BRCA1/2 breast cancer

ECCO Highlights Day 2: Breast and Ovarian Cancer

The latest data on BioMarin's PARP inhibitor BMN 673 in breast and ovarian cancer from ECCO 2013

September 29, 2013
Source: Ariad

ECCO 2013 Notes from the Road – Day 1

Update on ipilimumab, AP26113, T-DM1, everolimus and others from Day 1 at the 2013 ECCO meeting in Amsterdam.

September 28, 2013
ECCO 2013 Amsterdam

ECCO 2013: Is ODM-201 too late to the prostate cancer party?

At ECCO 2013 in Amsterdam, positive data was presented from the phase 1/2 clinical trial for ODM-201 (Orion) a second generation AR antagonist. In contrast the data for ASP9521 (Astellas), a novel androgen biosynthesis inhibitor was negative.

September 29, 2013
photo credit: Claudio.Ar via photopin cc

Preview of key ALK lung cancer abstracts at ECCO 2013

Review of the key abstracts in EML4-ALK lung cancer abstracts being presented at ECCO 2013 in Amsterdam.

September 23, 2013
ECCO 2013 Conference Amsterdam

A top line look at the PD-1 and PD-L1 abstracts at ECCO 2013

A quick review of the check point immunotherapy abstracts from #ECC2013 in Amsterdam.

September 19, 2013
With permission from Dr Wolchok

How new approaches in targeted immunotherapy with anti-PD-1 and PD-L1 may change cancer research

Overview of anti-PD-1 and PD-L1 immunotherapies plus ASCO 2013 data in melanoma and lung cancer.

September 18, 2013

Preview of 2013 European Cancer Congress in Amsterdam

2013 European Cancer Congress organized by ECCO takes place in Amsterdam from September 27 to October 1st. This is a preview of some of the abstracts to watch out for at the meeting.

September 16, 2013
Ibrutinib Pharmacyclics ASH 2012

Ibrutinib leads the race to CLL 17p deletion market

Earlier this month, Janssen/Pharmacyclics announced they had submitted a New Drug Application (NDA) for FDA approval of ibrutinib, an oral Bruton’s tyrosine kinase inhibitor (BTK) in chronic lymphocytic leukemia (CLL) for the treatment of patients with a deletion of the short arm of chromosome 17 (del17p). Approval later this year or in early 2014 is highly likely given that ibrutinib has already been designated a Breakthrough Therapy by the FDA.

July 29, 2013
Takeda Orternel Press Release

Orteronel (TAK-700) fails in Advanced Prostate Cancer

Takeda’s orteronel (formerly known as TAK-700) may be on its way to “dog drug heaven” after an interim analysis of the ECM-PC 5 phase 3 clinical trial showed that men with advanced prostate cancer taking the drug did not live significantly longer (HR 0.894, p=0.226) than those taking an inactive placebo.

July 26, 2013
Aragon Pharma Website

JNJ acquisition of Aragon ARN-509 deals a blow to Medivation

Johnson & Johnson (JNJ) just announced the acquisition of privately-held Aragon Pharmaceuticals and the rights to ARN-509 a second-generation androgen receptor antagonist that will be a future competitor to Medivation’s Xtandi.

June 17, 2013
Dr-Susan O'Brien

ASCO 2013 Video Interview with Dr Susan O’Brien on CLL new drugs in development

It's exciting times in Chronic Lymphocytic Leukemia (CLL) with a lot of new data expected at the forthcoming 2013 annual meeting of the American Society of Hematology (#ASH13) in New Orleans. At ASCO 2013, Dr Susan O'Brien shared her thoughts on several new CLL drugs in development including ABT-199, ibrutinib, idelalisib, AV-292, obinutuzumab and IP-145.

June 10, 2013
ASCO 2013 Celgene Pancreatic Cancer Sign

ASCO 2013 Abraxane in pancreatic cancer is a welcome new treatment option

At ASCO 2013 the phase III MPACT trial data for Abraxane in pancreatic cancer was presented. This data was first reported at ASCO GI earlier this year. Abraxane in pancreatic cancer is a welcome new treatment option but it is not a major breakthrough that offers a dramatic shift in outcome.

June 7, 2013
ASCO 2013 Chicago Skyline

AZD3514 Fails to Live up to Preclinical Promise in CRPC at ASCO 2013

The novel SARD inhibitor AZD3514 showed preclinical promise in advanced prostate cancer, but the phase 1 first-in-human clinical trial showed it had tolerability problems, and it's development in CRPC has been terminated by AstraZeneca.

June 6, 2013
ASCO 2013 Annual Meeting

ASCO 2013 Pfizer joins race to develop a Herceptin biosimilar with PF-05280014

At ASCO 2013, there was a lot of interest in a poster on Pfizer's PF-05280014, a potential biosimilar to Herceptin.

June 5, 2013
ASCO 2013 Charles Sawyers Science of Cancer Award

ASCO 2013: Cancer Drug Combinations are The Future

At ASCO 2013 Dr Charles Sawyers received the 2013 Science of Oncology Award, after which he gave an insightful lecture on Overcoming Resistance to Cancer Drug Therapy. His message was clear that combinations of cancer drugs are the future.

June 3, 2013
ASCO 2013 CLL New Treatments

ASCO 2013 CLL Runners and Riders in Race to Market #ASCO13

New clinical data on ibrutinib, obinutuzumab, idelalisib, IPI-145, ABT-199 for the treatment of Chronic Lymphocytic Leukemia (CLL) will be presented at ASCO 2013.

May 28, 2013

ASCO 2013 Preview Video

ASCO 2013 Preview Video of what's hot at the meeting for cancer new products in immunotherapy, CLL, breast cancer, lung cancer and breast cancer. Includes a MOA of PD-L1.

May 28, 2013
AACR 2013 Annual Meeting Washington DC

AACR 2013 Posters offer Insights into Biotech Drug Development

The poster sessions at the 2013 annual meeting of the American Association for Cancer Research (AACR) are not all about mice, and test tubes, but offer insights into biotech drug development, new targets and licensing opportunities.

April 15, 2013
White House Washington DC

AACR 2013 posters show potential new Pfizer cancer drugs

My overriding impression of large cap Pharma R&D from the 2013 annual meeting of the American Association for Cancer Research (AACR) was that Novartis and Genentech remain the front-runners in cancer drug development, with Pfizer very much up and coming.

April 12, 2013
Power of Social Media

AACR 2013 Cancer Scientists fail to embrace Social Media

Cancer scientists have not embraced social media in the way cancer doctors and patient advocates have. To support public funding of research, cancer scientists need to communicate the value of the scientific research they conduct. One way to do this is to embrace social media more, particularly at meetings such as AACR, where there is the opportunity to share information with a worldwide audience.

April 11, 2013
AACR 2013 Annual Meeting

AACR 2013 GDC-0032 a next generation PI3K Inhibitor shows early promise in breast cancer

GDC-0032 is a next generation PI3K inhibitor that spares the beta-isoform of PI3K. Genentech hypothesize this may reduce some of the undesired side effects such as effects on metabolism, previously seen with pan PI3K inhibitors such as GDC-0941. At AACR 2013 promising early clinical data was presented for GDC-0032 in PI3KCA mutant cancers, especially breast cancer.

April 8, 2013
Washington Monument Cherry Blossom

AACR 2013 DMUC5754A is a novel agent for Ovarian Cancer

AACR 2013: A late-breaking clinical trial presentation to watch is LB-290: Targeting MUC16 with the Antibody-Drug Conjugate DMUC5754A in patients with platinum-resistant ovarian cancer. This data will be presented by Joyce Liu, MD, MPH from Dana-Farber Cancer Institute in the Clinical Trials Symposium on Tuesday, Apr 9 at 4.00 pm.

April 7, 2013
Tokai Poster Title Crop

What is the potential for galeterone in advanced prostate cancer?

Tokai Pharmaceuticals have yet to show the new formulation of galeterone is safe and effective or that men with advanced prostate cancer live longer when taking the drug compared to taking abiraterone or enzalutamide either sequentially, or in combination. While galeterone may offer an innovative mechanism of action, it is too early to say what potential it may have in the treatment of advanced prostate cancer.

March 6, 2013
Cancer Discovery Cover Feb 2013 Screenshot

Inhibitors of Apoptosis Target one of the Hallmarks of Cancer

Inhibitors of apoptosis proteins IAP such as Novartis LCL161 and Curis CUDC-427 are new cancer drugs to watch. However recent research published in the AACR journal Cancer Discovery raises the question of whether IAP-antagonist-based therapy may require concomitant use of drugs that prevent bone resorption.

February 28, 2013
Clinicaltrials.gov snapshot Feb 14, 2013

ABT-199 clinical trials suspended after patient death $ABBV

Following a death due to tumor lysis syndrome, AbbVie ($ABBV) have suspended the ABT-199 clinical trial program. ABT-199 is a promising new drug in development for chronic lymphocytic leukemia (CLL) that was about to enter phase 3 drug development by the company.

February 15, 2013

Dasatinib fails in Prostate Cancer #GU13

ASCO GU 2013: dasatinib phase 3 clinical trial fails to show any survival benefit in men with advanced prostate cancer when used in combination with docetaxel chemotherapy. However whether there are a subset of advanced prostate cancer patients who might respond to the bone-targeted effects of the drug remains open to question.

February 12, 2013
ASCO GU 2013 takes place in Orlando, Florida.

ASCO GU 2013 Prostate Cancer Preview #GU13

At the ASCO GU 2013 meeting in Orlando, Bristol Myers Squibb will publish the results of the dasatinib (Sprycel) phase 3 prostate cancer trial. New data on abiraterone, alpharadin, ARN-509 and enzalutamide is also expected.

February 1, 2013
ASH 2012 Ernest Beutler Lecture

ASH 2012: CTL019 chimeric antigen receptor technology emerging as a new leukemia treatment

For many attendees, the most exciting news at the 2012 annual meeting of the American Society of Hematology (ASH) held last December in Atlanta was the prospect of personalized T cell therapy for the treatment of patients with B cell cancers such as chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL).

January 15, 2013
ASH 2012 Meeting Atlanta

ASH 2012: ABT-199 shows promise in CLL and MCL

ABT-199 is an exciting new agent in development with potential as a new treatment option for CLL & MCL. It is a potent and selective BCL-2 inhibitor that has been engineered not to cause the dose-dependent thrombocytopenia seen with navitoclax.

January 7, 2013
Medivation v University of California IP dispute court docket

Court rules Medivation has no IP rights to Aragon Pharmaceuticals ARN-509 $MDVN

Medivation investors hoping for a windfall will be disappointed to hear that on December 20, 2012 a California judge ruled the company had no rights to what is now known as Aragon Pharmaceuticals ARN-509, a next-generation androgen receptor (AR) antagonist for advanced prostate cancer, similar in chemical structure to enzalutamide (Xtandi)

January 3, 2013
FDA Cancer Related NME Approvals 2012

2012 was a Grand Cru year for the FDA with 39 NMEs approved

FDA approved 39 new molecular entities in 2012. This is the highest number in the last 10 years. However, approval rate is not a surrogate benchmark for the state of innovation given that it can take several years to bring a new drug or biologic to market.

January 2, 2013
View of San Antonio Breast Cancer Symposium 2011

Who to follow at #SABCS San Antonio Breast Cancer Symposium

The overall survival data for the CLEOPATRA trial will be presented next week at the San Antonio Breast Cancer Symposium. Here's my list of a few people to follow on Twitter for news and commentary from the meeting.

November 29, 2012
Adcetris MOA at ASH 2011 Annual Meeting

Who to follow at #ASH12 American Society of Hematology Annual Meeting in Atlanta

Without wishing to offend anyone, here’s my list of people to follow on Twitter at #ASH12, the 2012 annual meeting of the American Society of Hematology in Atlanta from December 8 – 11

November 27, 2012
Dr Jagannath presented on Multiple Myeloma at Chemotherapy Foundation Symposium

The Evolving Multiple Myeloma Landscape

Dr Sundar Jagannath from Mt. Sinai School of Medicine discussed new IMiD and Proteasome Inhibitors for the treatment of Multiple Myeloma at the 2012 Chemotherapy Foundation Symposium in New York.

November 9, 2012
Hagop Kantarjian M.D. presented on CML treatment choices at the 2012 Chemotherapy Foundation Symposium in New York

The Evolving CML Market – which drug to give when?

Dr Hagop Kantarjian from The MD Anderson Cancer in Houston discussed chronic myeloid leukemia (CML) treatment options at the 2012 Chemotherapy Foundation Symposium in New York.

November 8, 2012
biomarkers-consortium logo

Improving Clinical Trials through the use of Biomarkers

Biomarkers can be used for diagnosis and for monitoring the safety and effectiveness of treatments. They are increasingly becoming important in the selection of patients for clinical trials, and as potential surrogates for clinical endpoints that may take a long time to occur e.g. measuring how long someone will live in a cancer trial (overall survival).

August 29, 2012
BMS Sprycel Logo

Will dasatinib be effective in prostate cancer?

The results of the phase 3 prostate cancer trial for dasatinib in combination with docetaxel are expected soon.

October 22, 2012
AB Science Logo

AB Science files for Pancreatic Cancer approval

AB Science has filed for European approval of mastinib in pancreatic cancer with the European Medicines Agency based on data that showed masitinib significantly increased survival in a subset of patients with a novel genetic biomarker. Data will be presented at 2013 ASCO GI symposium.

October 18, 2012
Gefitinib Esophageal Cancer ESMO 2012

ESMO 2012 Gefitinib in Esophageal Cancer – can we identify the responders?

At ESMO 2012 Professor David Ferry reported the results of the Cancer Oesophagus Gefinitib (COG) study that looked at whether gefitinib (Iressa) could improve overall survival in esophageal cancer patients who had progressed after chemotherapy.

October 1, 2012
ODM-201 Trial

ESMO 2012 ODM-201 shows promise as a future competitor to enzalutamide

ODM-201 is a second generation androgen-receptor AR antagonist from Orion Pharma in early stages of clinical development.

September 30, 2012
TH-302 ESMO 2012

ESMO 2012: TH-302 Pancreatic Cancer Survival Data Fails to Impress

Results were presented at ESMO 2012 for the TH-CR-404 phase 2 clinical trial that compared the efficacy and safety of TH-302 (Threshold Pharmaceuticals) plus gemicitabine versus gemcitabine alone in patients with untreated advanced pancreatic cancer.

September 30, 2012
ODM-201 Orion Pharma

ESMO 2012: ODM-201 a new generation antiandrogen for advanced prostate cancer

One of the late-breaking abstracts that I am looking forward at the forthcoming annual Congress of the European Society for Medical Oncology (ESMO 2012) in Vienna is on ODM-201, a new prostate cancer drug from Orion Pharma.

September 18, 2012
ESMO 2012 Congress

ESMO 2012 Vienna Congress Plenary Preview #ESMO12

Preview of late breaking abstracts to be presented in Presidential Symposia at the European Society of Medical Oncology ESMO 2012 Congress in Vienna

September 5, 2012
Pivot Prostate Cancer Trial Conclusion

Urologist Castrates Media over Reporting of PIVOT Prostate Cancer Trial

Dr Benjamin J. Davies from University of Pittsburgh criticizes the media reporting of the Prostate Cancer Intervention versus Observation Trial (PIVOT).

August 7, 2012
Human thyroid  with cancer nodules. 
Photo Credit: Dr Jeffrey Norton/NCI

NEJM reports trial of Veracyte thyroid cancer diagnostic test, is it worth $4,200?

Detecting thyroid cancer early and avoiding unnecessary surgery is the potential promise of a new diagnostic test.

June 28, 2012
Lake Tahoe Pancreatic Cancer Conference

BAY 86-9766 shows early promise at AACR Pancreatic Cancer Conference

A diagnosis of stage IV pancreatic cancer is pretty much a death sentence. There is, therefore, an unmet need for effective new pancreatic cancer treatments.

June 25, 2012
Radium-223 Delays time to first SRE

Problems with Alpharadin ASCO SRE data?

Algeta says there are "discrepancies" in the skeletal-related event (SRE) data presented at ASCO 2012

June 15, 2012
ASCO 2012 CRPC Prostate Cancer Education Session

ASCO 2012 What is the Optimal Sequencing of Advanced Prostate Cancer Drugs?

Oliver Sartor, Professor of Cancer Research and Medical Director of the Tulane Cancer Center in New Orleans says there is "no data" (yet) on the optimal sequence for new advanced prostate cancer drugs.

June 7, 2012
Abiraterone Acetate Pre-Chemotherapy ASCO 2012

ASCO 2012: Zytiga fails to show overall survival pre-chemo

For abiraterone acetate (Zytiga®) in the pre-chemotherapy setting i.e for asymptomatic or mildly symptomatic men, doctors will not be able to tell patients that they will live longer if they take it.

June 4, 2012
American Urological Association 2012 Annual Meeting

AUA 2012 Twitter Conference Coverage #URO12

If you missed the tweets from the 2012 annual meeting of the American Urological Association in Atlanta, you can read them here.

May 17, 2012
AACR 2012 Annual Meeting Posters Piramal Healthcare

AACR 2012: Promising CML & PI3K compounds from Indian company Piramal Healthcare

Piramal Healthcare presented posters on early-stage drug development compounds, including: P7170, a Phosphoinositide 3-Kinase (PI3K)-mammalian Target of Rapamycin (mTOR) and Activin Receptor-Like Kinase 1 (ALK1) inhibitor & P2745, an orally bioavailable molecule effective in imatinib resistant chronic myeloid leukemia cell lines including those with the T315i mutation.

April 24, 2012
AACR 2012 Jeffrey Engelman Strategies to Overcome Resistance

AACR 2012: Future is combinations of novel cancer agents

The future of cancer drug therapy is likely to involve combinations of novel cancer agents. Jeffrey Engelman from MGH persuasively presented on why we need combination therapies to overcome resistance.

April 23, 2012
Bcl-2 is a signaling pathway for the regulation of apoptosis

AACR 2012: ABT-199 is a new Bcl-2 inhibitor with potential in Chronic Lymphocytic Leukemia

ABT-199, a potent and selective inhibitor of Bcl-2. Steven Elmore from Abbott Laboratories presented impressive early data from an ongoing phase I trial in patients with chronic lymphocytic leukemia (CLL).

April 20, 2012
Bill Sellers VP Global Head Oncology Novartis Institutes for BioMedical Research

AACR 2012: the automation of preclinical drug discovery will be a driver of innovation

One enduring image I have from the plenary presentation on "The Genetic Basis for Cancer Therapy" by Bill Sellers, VP/Global Head Oncology at Novartis Institutes for BioMedical Research was the video he showed of the robots that are used for automated cell profiling.

April 18, 2012
2012 Annual meeting of American Association for Cancer Research in Chicago. Photo Credit: Pieter Droppert

AACR 2012: AZD3514 a new prostate cancer drug to watch

One prostate cancer new product that caught my attention at AACR 2012 as one to watch is AZD3514.

April 17, 2012
Maha Hussain MD

Cabozantinib Mechanism of Action – Part 3 of an interview with Dr Maha Hussain

Dr Hussain discusses the scientific rationale behind the mechanism of action for cabozantinib, a multi-kinase inhibitor of C-MET, VEGF and others.

March 16, 2012

Cabozantinib Prostate Cancer Bone Scans – Part 2 of an interview with Dr Maha Hussain

At the 2011 ASCO annual meeting, Dr Hussain presented data from a non-randomized phase 2 trial with cabozantinib that showed dramatic improvements in bone scans before and after treatment.

March 14, 2012
Image Source: Exelixis

Cabozantinib & Pain in Prostate Cancer – an interview with Dr Maha Hussain

"My average patient is interested in living longer, not just in controlling their pain." Dr Maha Hussain

March 12, 2012

The Mannogram – how imaging may revolutionize prostate cancer diagnosis

Professor Barentsz described how advances in magnetic resonance imaging (MRI), and in particular multi-parametric MRI (Mp-MRI) offer the potential for the improved detection and characterization of prostate cancer.

March 8, 2012

PIVOT data continues to show no survival benefit for prostatectomy over watchful waiting in men with low to medium risk early prostate cancer

Timothy J. Wilt MD, MPH presented an update on the VA, NCI, AHRQ Prostate cancer Intervention Versus Observation Trial (PIVOT) on the final day of the 2012 European Association of Urology (EAU) Congress in Paris.

March 6, 2012
da Vinci surgery system

Why don’t we have evidence based medicine for robot-assisted radical prostatectomy?

Professor Walter Artibani told the assembled media that urologists had failed as scientists in not generating robust clinical data to support the use of the da Vinci robotic system for the removal of the prostate gland (prostatectomy).

March 5, 2012
EAU 2012 TAK-700 Orterernol Poster

Update on Orteronel TAK-700 from EAU 2012 Paris #EAU12

Orteronel (TAK-700) is a selective, non-steroidal inhibitor of 17, 20 lyase, a key enzyme involved in the production of androgens such as testosterone. This is a similar mode of action to abiraterone acetate (Zytiga).

February 26, 2012

Alpharadin Expanded Access Program is Recruiting #EAU12

Bayer have opened an Expanded Access Program for Alpharadin, that allows eligble advanced prostate cancer patients access to this radiopharmaceutical pending regulatory approval.

February 25, 2012

European Association of Urology 2012 #EAU12 Twitter Coverage

Aggregation of #EAU12 tweets for those interested in following twitter coverage of the meeting in Paris.

February 24, 2012
Oliver Sartor MD Tulane

ASCO GU: radium-233 Alpharadin significantly prolongs time to first Skeletal Related Event

radium-223 in bone-metastatic castration resistant prostate cancer patients (CRPC), not only significantly prolonged time to first skeletal related event (SRE), but significantly prolonged 3 out of the 4 SRE components.

January 31, 2012
Geoffrey Childs, Ph.D

Challenges with Head and Neck Cancer Drug Development

Low-level expression of micro RNA-375 (miR-375) correlated with poor outcome in tumors of HNSCC patients.

January 25, 2012

Preview of ASCO GU 2012 Prostate Cancer Data

My preview of prostate cancer abstracts that caught my attention.

January 20, 2012

Targeting IDH1 in Glioma Patients

One of the challenges of the next decade in cancer research will be targeting cancer metabolism; imaging…

January 17, 2012
JCO Barry Paper Banner

Robotic Assisted Prostate Surgery does not lead to fewer complications

A survey of patients who had their prostate removed showed there was no significant difference in complication rates between open retropubic radical prostatectomy (ORRP) and robotic assisted laparoscopic surgery (RALRP).

January 6, 2012

Radotinib approved in South Korea for CML

The South Korean equivalent of the FDA have approved radotinib (Il-Yang pharmaceuticals) or chronic myeloid leukemia (CML).

January 5, 2012
View of San Diego from ASH 2011

Which posters were hot at ASH 2011?

This post highlights a few of the 4000+ posters that appeared to attract a lot of interest at the 2011 American Society of Hematology (ASH) annual meeting.

December 16, 2011
ASH 2011 Poster Viewing

AML update from 2011 ASH annual meeting

FLT3 has been shown to be prognostic of poor survival, but is it an attractive molecular target in AML?

December 15, 2011

CML update from 2011 ASH annual meeting

The most newsworthy CML data presented at the meeting was on Ponatinib. Jorge Cortes (MD Anderson Cancer Center) presented the phase II results from the PACE (Ponatinib Ph+ ALL and CML Evaluation) clinical trial.

December 14, 2011
The Alamo San Antonio

What role do macrophages play in breast cancer?

At the 2011 San Antonio Breast Cancer Symposium, Lisa Coussens (USCF) described how understanding the biology of macrophages and the importance they play in breast cancer may lead to new drug targets.

December 9, 2011

Can you reduce your environmental risk of breast cancer?

At the San Antonio Breast Cancer Symposium (SABCS), the Institute of Medicine (IOM) report on “Breast Cancer and the Environment” was eagerly anticipated.

December 7, 2011

Photoimmunotherapy may be a new way to deliver molecular-targeted cancer drugs

Photoimmunotherapy (PIT) that uses a near-infrared (NIR) dye conjugated to monoclonal antibodies (mABs) that target epidermal growth factor receptors (EGFR) is a new type of molecular-targeted cancer therapy that appears to offer considerable promise.

December 1, 2011

Overcoming barriers to new cancer drug development

William N. Hait MD, PhD, global therapeutic area head of oncology, Johnson & Johnson presented a plenary session on "overcoming barriers to new drug development" at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International Conference in San Francisco.

November 21, 2011

Improving Cancer Clinical Trial Design #AACR Molecular Targets

Commentary on educational session on "Clinical Trial Paradigms in the Era of Novel Therapies” at the AACR-NCI-EORTC international conference on Molecular Targets and Cancer Therapeutics in San Francisco

November 18, 2011
Times Square NYC

Chemotherapy Foundation Symposium Prostate Cancer Update

The 8am session at the Chemotherapy Foundation Symposium (The Greenspan Meeting) in NYC featured a review of current developments in Prostate Cance

November 11, 2011

A potential new Immunotherapy in Breast and Ovarian Cancer

Researchers from the National Cancer Institute (NCI) have published data from a small pilot trial showing a clinical response to a poxviral vaccine (PANVAC) in metastatic breast cancer and ovarian cancer patients.

November 9, 2011

MDV3100 shows survival in Advanced Prostate Cancer

MDV3100 produced a 4.8-month advantage in median overall survival compared to placebo. The estimated median survival for men treated with MDV3100 was 18.4 months compared with 13.6 months for men treated with placebo.

November 3, 2011

New Imaging Agents may improve Glioblastoma Surgery

Colin Watts from the University of Cambridge, will treat patients with 5-Amino-Levulinic Acid (5-ALA), a metabolic marker of malignant glioma cells. 5-ALA is preferentially taken up by brain tumor cells and then converted into a strongly fluorescing porphyrin.

November 1, 2011

Vitamin E may improve gemcitabine effectiveness in pancreatic cancer

Tocotrienols (unsaturated form of Vitamin E) may have a potential role to play in anti-cancer therapy

October 14, 2011

Vitamin E supplements lead to 17% increase in Prostate Cancer

Despite promising preclinical data suggesting that selenium and vitamin E may reduce prostate cancer risk, a randomized trial started in 2001 with over 35,000 men now suggests otherwise.

October 11, 2011
USPTF Screening

Prostate Cancer Screening – the debate continues

Opinion remain divided over the use of prostate-specific antigen (PSA) screening

October 10, 2011
Alpharadin Dr Chris Parker Interview

radium-223 Alpharadin in Advanced Prostate Cancer – an interview with Dr Chris Parker

A video interview with Dr Chris Parker at EMCC 2011 in Stockholm about radium-223 (Alpharadin).

October 3, 2011

EMCC 2011 Patient advocacy session on Cancer & the Internet

The internet can help patients with rare diseases have a voice with policy makers. This session also showcased the new European cancer portal: ecancerHub

September 30, 2011
Alpharadin Media Briefing EMCC 2011

ECCO ESMO 2011 radium-223 Alpharadin media briefing video

Dr Chris Parker presented the phase 3 ALSYMPCA prostate cancer trial results for radium-223 chloride (Alpharadin) at the 2011 European Multidisciplinary Cancer Congress in Stockholm.

September 29, 2011

Alpharadin wlll be new treatment option for Prostate Cancer

Radium-223 (Alpharadin) shows an overall survival benefit in men with symptomatic bone metastases and castration-resistant prostate cancer.

September 25, 2011
EMCC 2011 Michael Baumann

Alpharadin Prostate Cancer data will be “Practice Changing” #EMCC2011

Radium-223 (Alpharadin) will be “Practice Changing” is how Michael Baumann, President of the European CanCer Organisation (ECCO) and Jean-Charles Soria, Co-Scientific chair of the 2011 Stockholm Multidisciplinary Cancer Congress described the prostate cancer clinical trial data to be presented in the Presidential (plenary) session.

September 23, 2011

Alpharadin on fast track to FDA prostate cancer approval in 2012

Bayer & Algeta have announced that Alpharadin™ (radium-223 chloride) has received Fast Track designation from the FDA for the treatment of castration-resistant prostate cancer (CRPC)

August 25, 2011

Zytiga European Prostate Cancer approval may kill Jevtana sales

Jevtana simply came to the market too late in Europe, and Zytiga gained accelerated approval. It’s a reminder that we live in a dynamic pharmaceutical market place.

August 4, 2011
EHA 2011 CML Patient Adherence

Patient advocacy session at European Hematology Association EHA 2011 Congress shows impact of drug adherence on outcome

Adherence to chronic myeloid leukemia (CML) therapy is the critical factor for achieving molecular responses.

June 15, 2011

Prostate Cancer Market to expand from $1B to $5B by 2015

The market for prostate cancer therapies is set to expand from $1 billion currently to $5 billion by 2015, according to analysts.

June 2, 2011

ASCO 2011 Cabozantinib (XL184) may be an exciting new prostate cancer drug

It will be interesting to see whether cabozantinib can impact overall survival (OS) in advanced prostate cancer, something that denosumab (Xgeva®) failed to show in the 147 trial that was just presented at AUA.

May 19, 2011

AUA 2011 Results from PIVOT study show no benefit from radical prostatectomy in low risk early stage prostate patients

Data from the Prostate Cancer Intervention versus Observation Study (PIVOT) was presented in the plenary session of the 2011 annual meeting of American Urological Association (AUA)

May 17, 2011

AUA 2011 European men with a biochemical recurrence have a lower prostate cancer survival compared to the United States

Presented by Alex Haese from Hamburg, Germany, this paper was a retrospective analysis of 1,574 patients who had a biochemical recurrence (PSA > 0.2 mg/dl) following RP.

May 17, 2011

AUA 2011 New Prostate Cancer products in development beyond the androgen axis

Focusing on adrenal steroid inhibition or blocking the androgen receptor may not be sufficient to prevent disease progression. If we are looking for a Prostate Cancer cure, then will it may take multiple drugs, including those that target various stromal sites.

May 16, 2011

Of Mice and Men

The March 17, 2011 edition of Nature, highlights how innovative preclinical animal models are having an impact on drug development.

March 25, 2011

AB Science – realizing the potential of masitinib in cancer and inflammation

Masitinib is a multi-kinase inhibitor that inhibits wild type and mutant forms of stem cell factor receptor (c-KIT, SCFR), platelet-derived growth factor (PDGFR), fibroblast growth factor 3 (FGFR3) and to a lesser degree, focal adhesion kinase (FAK)

February 23, 2011

Gilead acquires Calistoga and CAL-101 for $375M

In an acquisition that highlights the importance of cancer and inflammation, Gilead Sciences today announced the acquisition of Seattle based Calistoga Pharmaceuticals for $375M.

February 22, 2011

Hypoxia and Inflammation: is HIF-1 a target for drug development?

HIF-1 overexpression is associated with tumor growth, vascularization and metastasis. This has led to HIF-1 being evaluated as a target for anti-cancer drugs.

February 22, 2011

Insights of the Decade

The December 17, 2010 issue of "Science" has the catchy of title of "Insights of the Decade", one of which is the ubiquitous role of inflammation in multiple chronic illnesses including cancer.

January 3, 2011

Targeting BAP1 – a future targeted therapy for Uveal Melanoma?

Results published in Science, “implicate loss of BAP1 in uveal melanoma metastasis and suggest that BAP1 pathway may be a valuable therapeutic target.”

December 21, 2010