Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Cancer Immunotherapy

Posts tagged ‘AACR 2016 Immuno-Oncology’

New Orleans StreetCarNew Orleans – the annual meeting of the American Association for Cancer Research (AACR) starts in earnest today with a full program of educational sessions presented by leading experts in different fields.

There’s a lot going on at AACR, with many sessions in parallel, so always remember the “law of two feet” – if the session you are in isn’t interesting, what you expected or isn’t meeting your needs – get up and go to another one!

Starting today and through Tuesday will be posting a daily blog with commentary around the sessions we attend and the people we speak to. It won’t be real-time, but to the extent possible we’ll be providing updates during the day.

It kills us to do semi-live posts from conferences, but they’re popular with subscribers, many of whom enjoy reading top-line commentary during the meeting, then our in-depth pieces later.

If you’d like to join the club of readers who enjoy access to our content, much of which by definition is exclusive – we don’t think anybody else does what we do or talks to as many thought leaders….

The good news is that a quarterly subscription will also cover you for ASCO 2016 in Chicago.  If you’d like to support our conference coverage, you can purchase access below. Subscribers can login to read more.

St Charles Streetcar New OrleansIt’s Day 4 of our Road to AACR 2016 mini-series

In the run up to the start of the annual meeting of the American Association for Cancer Research (AACR) that takes place in New Orleans from April 16 -20, we’re highlighting some of the hot topics and interesting targets with data to be presented at the meeting (Twitter #AACR16).

We’ll be providing conference coverage from AACR both during and after the meeting. The program this year offers a veritable smorgasbord of choices, particularly in cancer immunotherapy. It’s going to be hard to cover every session we want to attend!

AACR will be webcasting many presentations, however, much of the work presented and discussed at AACR is unpublished and/or still a work in progress, so do check if a talk you are interested in will be webcast or not. The online meeting calendar indicates whether permission has been given and if all the slides will be included. If you really want to hear something do get to meeting rooms early; we expect the cancer immunotherapy sessions will be especially popular!

In today’s post we’re looking at what’s new at AACR 2016 for cancer immunotherapies that target IDO1 and TDO and their downstream effectors.

Tumor cells and myeloid cells in the microenvironment express high levels of indoleamine-2,3-dioxygenase 1 (IDO1). IDO1 is a rate-limiting enzyme in the degradation of the amino acid tryptophan (TRP). Depletion of tryptophan inhibits T cell responses.

Another route by which the tryptophan metabolic pathway can lead to immunosuppression is via the enzyme TRP-2,3-dioxygenase 2 (TDO), which may be an additional target for cancer immunotherapy. Some IDO1 inhibitors also inhibit TDO, others don’t, which makes for an interesting question as to whether you need a dual-targeted approach or not?

In this post we’re looking at:

  • Some of the companies who have IDO1/TDO inhibitors in development – there is a surprising amount of activity!
  • What is the right combination partner?
  • Who is most likely to benefit from IDO1/TDO cancer immunotherapy?

Data at AACR 2016 may help us answer some of the above questions, and we’ve showcased a few of the relevant sessions and presentations for your AACR “dance card” if this is an area of interest.

Subscribers can login to read more or you can purchase access below. This post is Day 4 of our Road to AACR 2016 mini-series.

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