San Francisco – In the ASCO GU prostate cancer session yesterday morning one of the most interesting presentations was by Andrew J Armstrong, Associate Professor of Medicine and Surgery at the Duke Cancer Institute.
I previously referenced Dr Armstrong’s excellent education presentation at ASCO 2012 in my piece on Xconomy about the emerging challenges of prostate cancer drug development.
He’s a speaker that I particularly enjoy listening to, so my attention was immediately drawn to his presentation at ASCO GU on, “Beyond Enzalutamide and Abiraterone: What’s Next in Androgen Therapy.”
Looking at this title, at first glance the question that comes to mind is do we really need new treatments that target the Androgen Receptor (AR), after all we’ve heard this week about the PREVAIL trial with enzalutamide?
Based on Dr Armstrong’s presentation the answer is a resounding yes!
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This week sees the start of the American Society of Clinical Oncology Symposium on Genitourinary Cancers (ASCO GU) in San Francisco.
Prostate cancer has certainly been in the minds of investors the past few weeks in anticipation of the COMET-1 prostate cancer trial results for cabozantinib (Cometriq).
The share price went on a run-up until Exelixis CEO Michael Morrissey took yet another trip to the biotech ATM machine. Somehow, this doesn’t come as any surprise given past performance. The key issue at stake here, however, is will the COMET-1 trial be positive or negative? The outcome is much anticipated and will no doubt influence the chances of successful approval for cabozantinib in advanced prostate cancer. Data is expected sometime in first half of this year.
What we can expect in the media this week is more news on the Medivation and Astellas phase 3 trial PREVAIL clinical trial of enzalutamide (Xtandi) in men with advanced prostate cancer who had not yet received chemotherapy. The ASCO GU abstracts are publicly available at 5pm on Tuesday.
Currently, the key data from oncology medical conferences is focused squarely on Medivation’s enzalutamide and the PREVAIL data. It seems a good idea to discuss what are the key things to watch out for?
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