Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Cancer Immunotherapy

Posts tagged ‘ASH15’

In the last of our American Society of Hematology (ASH) 2015 annual meeting previews, we take a broad look at a host of intriguing abstracts in a variety of different topics that haven’t been covered in the rest of the series.

We also take a look a drug that has had a chequered history in the past, namely venetoclax, from the folks at AbbVie and Genentech. Is this a dud destined for dog drug heaven, or will it make a roaring comeback, breathing fresh life into hematologic malignancies such as chronic and acute leukemias, lymphomas and even multiple myeloma?

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ASH 2014 cHL PembroOne of the hotly debated topics at the 2014 American Society of Hematology (ASH) annual meeting was the arrival of checkpoint data in classical Hodgkin’s lymphoma (cHL), with initial data presented on 20-30 patients with relapsed or refractory cHL who received either nivolumab (BMS) or pembrolizumab (Merck) in open label, single agent trials.

Updated phase I data is expected to be presented at the 2015 ASH annual meeting in Orlando (Dec 5-8) (Twitter #ASH15)

At the recent ESMO symposium on Immuno-Oncology in Lausanne (Twitter #Immuno15) – great hashtag, there was an excellent overview of checkpoint blockade in lymphomas. What did this tell us about progress in this disease and where are things going?

ESMO-Symposium-on-Immuno-Oncology-2015-banner

The ESMO IO meeting set the scene for what we can expect at ASH this year?

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Downtown Disney Orlando

Downtown Disney, Orlando

It’s an exciting week for cancer drug development with the AACR-NCI-EORTC molecular targets meeting in Boston (Twitter: #Targets15) and the 2015 annual meeting of the Society for Immunotherapy of Cancer (SITC) at National Harbor, MD (Twitter: #SITC2015)

However, today’s news is the much anticipated release of the abstracts (apart from the late breakers and press program) for the 2015 American Society of Hematology (ASH) annual meeting (Twitter: #ASH15) that takes place in Orlando from December 5-8th. We’ll at the meeting for the blog.

There is so much great science at ASH, it’s really hard to do it justice – we’ve been known to spend most of the meeting in the poster halls…and until you see the data it’s impossible to provide detailed commentary or analysis.

However, there’s so much interest in the abstracts that for the benefit of our subs, I’ve highlighted several that caught my attention in what is a fast, real-time, top-line review while at SITC this morning.

This initial review covers two hot topics in cancer immunotherapy – CAR T cells and Checkpoint inhibitors.

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