Cabozantinib Prostate Cancer Bone Scans – Part 2 of an interview with Dr Maha Hussain
This is part 2 of my interview with Dr Maha Hussain, Professor of Medical Oncology at the University of Michigan. You can read part 1 about cabozantinib and pain here.
At the 2011 ASCO annual meeting, Dr Hussain presented data from a non-randomized phase 2 trial with cabozantinib that showed dramatic improvements in bone scans before and after treatment.
Bones are living tissues that are constantly being remade, a dynamic process that involves formation of new bone and taking up of old bone, a process known as bone resorption. Cancer cells can interfere with bone remodeling, resulting in increased new bone formation (osteoblastic response) or excessive bone resorption (osteoclastic response).
The recent AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics international conference in San Francisco was an informative meeting.