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Posts tagged ‘Dr Maha Hussain Interview’

Cabozantinib Mechanism of Action – Part 3 of an interview with Dr Maha Hussain

By on March 16, 2012

Maha Hussain MB ChB is Professor of Medical Oncology at the University of Michigan. I was privileged to interview her about cabozantinib (XL184), a novel drug in development for multiple indications, including prostate cancer.

You can read part 1 of the interview on cabozantinib and pain here, and part 2 about the bone effect seen with cabozantinib, here.

In this final post, Dr Hussain discusses the scientific rationale behind the mechanism of action for cabozantinib, a multi-kinase inhibitor of C-MET, VEGF and others.  She also shares her thoughts on where the scientific data suggests it should have most impact on prostate cancer.  I have emphasized in bold a few sections that stood out to me.

This is a preview of Cabozantinib Mechanism of Action – Part 3 of an interview with Dr Maha Hussain. Read the full post

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Cabozantinib Prostate Cancer Bone Scans – Part 2 of an interview with Dr Maha Hussain

By on March 14, 2012

This is part 2 of my interview with Dr Maha Hussain, Professor of Medical Oncology at the University of Michigan.  You can read part 1 about cabozantinib and pain here.

ASCO 2011 Cabozantinib Bone Scan Images 300x225 Cabozantinib Prostate Cancer Bone Scans Part 2 of an interview with Dr Maha Hussain

At the 2011 ASCO annual meeting, Dr Hussain presented data from a non-randomized phase 2 trial with cabozantinib that showed dramatic improvements in bone scans before and after treatment.

Bones are living tissues that are constantly being remade, a dynamic process that involves formation of new bone and taking up of old bone, a process known as bone resorption.  Cancer cells can interfere with bone remodeling, resulting in increased new bone formation (osteoblastic response) or excessive bone resorption (osteoclastic response).

This is a preview of Cabozantinib Prostate Cancer Bone Scans – Part 2 of an interview with Dr Maha Hussain. Read the full post

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