Biotech Strategy Blog

Commentary on Science, Innovation & New Products

Posts tagged ‘Drug Development Innovation’

TEDMED 2012: Francis Collins on how to brings drugs to market faster

If like me, you didn’t attend TEDMED in Washington DC, then you can now watch videos from the TEDMED 2012 conference.

With my interest in innovation and how to bring drugs to market faster, one video that caught my attention was by Francis Collins MD, PhD, Director of the National Institutes of Health (NIH) who talked about the challenges of going from basic science (fundamental knowledge) to its application.

In his presentation, Dr Collins talks about how it can take 14 years of research and the screening of 10,000 compounds to bring 1 new drug to market.

TEDMED 2012 Francis Collins Video Screen Shot 1 TEDMED 2012: Francis Collins on how to brings drugs to market faster

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AACR 2012: the automation of preclinical drug discovery will be a driver of innovation

There was so much good science on display at the recent 2012 annual meeting of the American Association for Cancer Research (AACR) in Chicago that any blog posts are but a personal snapshot or postcard.

AACR 2012 Bill Sellers Picture 300x168 AACR 2012: the automation of preclinical drug discovery will be a driver of innovationOne enduring image I have from the plenary presentation on “The Genetic Basis for Cancer Therapy“ by Bill Sellers, VP/Global Head Oncology at Novartis Institutes for BioMedical Research was the video he showed of the robots that are used for automated cell profiling.

Imagine the advertisements that show robots being used to build cars, but now the robots are undertaking automated laboratory work in pursuit of new cancer compounds. Wow!

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Innovation in combination trials of cancer targeted therapies

Academic institutions are now bringing pharma/biotech companies together and facilitating rational combination trials that make solid scientific sense.

Combining at least two targeted drugs looks to be increasingly necessary in order to develop innovative new cancer treatments, where turning off one target may stimulate another, thus both need to be targeted for there to be an overall effect.

However, one company may not have all the pathways and drug targets covered by their portfolio.  The result is that companies may have to work together in combination trials with each providing one drug from their portfolio.

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