Biotech Strategy Blog

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Posts tagged ‘nanomaterial’

Regenerative Medicine: Tissue Engineered Airway Transplant

Regenerative Medicine and the science behind replacing body parts with synthetic tissue engineered versions took another step forwards today after researchers announced they had transplanted a trachea made of a nanomaterial covered with the patient’s own cells.

seifaliancrowley crop 150x150 Regenerative Medicine: Tissue Engineered Airway Transplant

Researchers from University College London led by Prof. Alexander Seifalian designed and built a polymer based nanocomposite tracheal scaffold, which was then seeded with the patient’s own stem cells.

After two days in a bioreactor (Harvard Bioscience), the cells and the synthetic trachea scaffold were transplanted last month at the Karolinska University Hospital in Stockholm by Prof. Paolo Macchiarini and colleagues, into a patient with late stage tracheal cancer.

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How nanotechnology may revolutionize the detection of traumatic brain injury using a sensor that changes color

The highlight of the recent Association of Health Care Journalists (AHCJ) annual meeting in Philadelphia (Health Journalism 2011) for me was the presentation by Kacy Cullen from the Center for Brain Injury and Repair in the Department of Neurosurgery at the University of Pennsylvania.

© Kacy Cullen University of Pennsylvania 237x300 How nanotechnology may revolutionize the detection of traumatic brain injury using a sensor that changes color

© Kacy Cullen, University of Pennsylvania

Dr Cullen presented his research on blast-induced traumatic brain injury (bTBI) and the development of a nanomaterial containing photonic crystals that change color upon exposure to blast pressure.

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“Diamonds are Forever” – using nanodiamonds for drug delivery may improve the efficacy of cancer chemotherapy

Nanotechnology is set to have a major impact on drug development and new products for the diagnosis and treatment of cancer.  Research from UCSF and Northwestern University published earlier this year in “Science Translational Medicine” shows this potential.

Edward Chow and colleagues describe how binding the cancer chemotherapy doxorubicin (DOX) to carbon nanoparticles 2-8nm in diameter in the form of a diamond, “nanodiamond” (ND), improved drug efficacy and overcame drug resistance.  Although this pre-clinical animal research has not yet been confirmed in humans, it raises the possibility of more efficient chemotherapies and the hope of increased survival rates as a result.

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