Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Cancer Immunotherapy

Posts tagged ‘Nanomedicine’

American Urological Association 2012 Annual MeetingAlthough there is a lot of buzz around ASCO 2012 in a few weeks time, this weekend sees the start of the annual meeting of the American Urological Association (AUA) in Atlanta.  AUA 2012 runs from May 19-23 at the Georgia World Congress Center.

A few of the sessions that caught my attention include:

  • Basic Science Symposium on Nanomedicine and its application to urology. Several speakers will discuss how nanoparticles can be used for drug delivery, imaging and as therapeutic tools.
  • Society for Basic Urologic Research (SBUR) and Society of Urologic Oncology (SUO) joint meeting on personalized medicine and novel targets for cancer therapy.

For those of you who missed AUA 2011, you can obtain a flavor of the meeting from Sally Church’s video that was published on Pharma Strategy Blog.

If you can’t be in Atlanta, you can follow updates from the conference on Twitter (hashtag #UR012). A few people to follow at the meeting include @cooperberg_ucsf, @daviesbj, @MaverickNY@NeuroUroGastro.

We are aggregating the #URO12 tweets so you can easily catch up on the conversation and news below:

At the recent ARVO meeting, one of the symposia that I live tweeted from was on “Nanotechnology for Drug and Gene Delivery.”  During his presentation on “Nanomedicines: From Bench to Bedside” Vladimir Torchilin from Northeastern described how nanotechnology can use methods from other scientific disciplines including layer-by-layer (LbL) polymer chemistry.

Which leads me into an interesting paper that came across my desk from Zhiyong Poon and colleagues at the Koch Institute for Integrative Cancer Research at MIT.

In their paper published online on April 23, 2011 in ACS Nano. they describe how nanoparticles with a pH-sheddable layer can be used to target tumor hypoxia.

In other words, the nanoparticle can travel in the blood to the tumor, then in the changed acidity and pH of the tumor microenvironment, the outer stealth layer is eroded and shedded, exposing another layer of the nanoparticle that delivers drug to the target hypoxic tumor region.

Image Source:  ACS Nano. The author’s conclusion is that “this concept for tumor targeting is potentially valid for a broad range of cancers, with applicability for therapies that target hypoxic tumor tissue.”

This proof of principle research is further progress towards the development of nanomedicines in oncology.

ResearchBlogging.orgPoon, Z., Chang, D., Zhao, X., & Hammond, P. (2011). Layer-by-Layer Nanoparticles with a pH-Sheddable Layer for Targeting of Tumor Hypoxia ACS Nano DOI: 10.1021/nn200876f

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