Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Cancer Immunotherapy

Posts tagged ‘T790M negative’

Back Bay BostonNext week the Cancer Conference circuit moves on to a double-header with the AACR-NCI-EORTC Molecular Targets & Cancer Therapeutics meeting (Twitter #Targets15) taking place in Boston from November 5 – 9th, and the annual meeting of the Society for Immunotherapy of Cancer (SITC) taking place in National Harbor, MD from November 4 – 8th.

It is unfortunate that the two meetings clash, Molecular Targets is slightly later in the year than it was in 2013 when it was last in Boston. Both focus on the hottest topic in cancer drug development, which will come as no surprise… cancer immunotherapy.

In addition, in Boston there are some posters of note on other novel targets and approaches. Talking of which, Episode 7 of our Novel Targets podcast from the European Cancer Congress is now live. Do listen!

For this preview of #Targets15, we’ve taken a look at the abstracts that were published online yesterday afternoon (the late breakers and those in the press program are not available yet), and highlighted a few of interest, together with a few sessions of note.  If you have plans to be in Boston for the conference, this post will be of interest to you.

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As a heads-up, we will be at the forthcoming American Society of Hematology (ASH) annual meeting in Orlando (Twitter #ASH15), so if you have been sitting on the fence about buying a quarterly subscription, now is a great time to take the leap and join all those folks who want the “real edge” in cancer research.

You’ll obtain all the coverage we have planned over the next 3 months… Check it out!

Clovis Oncology RociletinibThe potential of Clovis Oncology’s EGFR inhibitor rociletinib (formerly CO-1686) to treat T790M negative non-small cell lung cancer (NSCLC) was one of the interesting talking points of the recent JP Morgan Healthcare conference in San Francisco (JPM15).

At the JP Morgan Healthcare Conference (JPM15), Clovis presented updated data that shows some efficacy in those NSCLC patients who no longer respond to an EGFR inhibitor, but don’t have a T790M mutation (T790M negative).  Both AstraZeneca’s competitor compound, AZD9291, and rociletinib shown considerable activity in those EFGR resistant patients who develop a T790M mutation and it’s likely they will both soon be approved in this indication, based on the encouraging data seen to date.

However, what is surprising and could be a key differentiation factor for Clovis, is if there is sufficient efficacy in T790M negative patients for use of the drug in this indication.

In this post, we discuss the potential of rociletinib in NSCLC T790M negative patients, whether thought leaders might use the drug in this indication, and delve deeper into the science behind the efficacy seen.

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