With so much data to cover recently, we haven’t have time for a perennial favourite, the monthly mailbag to answer BSB reader Q&A on hot oncology topics.
October has brought out quite a lot of controversy to consider, most of it happening in the last week!
Here, we consider questions on Immune Design’s phase 3 trial with their NY-ESO-1 vaccine, CMB305, which attracted both a lot of market attention and also questions from readers.
We also review a bunch of questions relating to 1L NSCLC and the upcoming readouts. This niche is probably potentially one of the most competitive spaces in oncology R&D at present and readers seem almost insatiable for information on this topic.
It is quite a turnaround considering the last decade of numerous failed trials or even non-inferiority studies that were being conducted.
Like many readers, I can well remember sitting in freezing cold, half empty halls wondering if the latest chemo or targeted therapy doublet was going to offer a mere 2-3 months improvement in PFS and no OS benefit or not. It was that binary and also depressing.
With the possibilities offered by immune checkpoint blockade, in a short space of time 1L NSCLC has gone from graveyard to uber intense with several companies vying to demonstrate improvements in overall survival by 6 months or more.
There’s a lot more to come here and not all of the lung trials will be positive – that’s expecting too much against the game of chance. Here, we look at numerous factors that could make a difference, both positive and negative.