Over the last five years we have followed the trials and tribulations of CAR T cell therapies in ALL and aggressive lymphomas as Novartis, Kite, Juno, Cellectis, Unum and others have undertaken the road less travelled towards filing and approval.

The ASH DASH in action!

Now that we have seen the first two CAR T cell approvals in pediatric ALL (Novartis) and aggressive lymphomas (Kite), with tisagenlecleucel widely expected to be the next one in aggressive lymphomas following presentation of the 6-month JULIET data at the recent American Society of Hematology (ASH) meeting in Atlanta, a key question remains to be addressed:

Is there a threat on the horizon that might be potentially used prior to CAR T cell therapy in refractory lymphomas?

We say ‘yes, there is’ and thus it was interesting to see where this approach might go… including discussion with an expert.

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