It’s time to talk about tackling solid tumours with CAR-T cell therapies.  In the past, this has been a challenging area with few or modest responses seen in people with advanced cancers.

As researchers go back to basics and think about both improving on the CAR construct design as well as fine tuning of the various elements, I am pleased to say things are finally looking a bit more upbeat on both sides of the pond.

Here we describe five very different strategies research groups are taking with a variety of different solid tumour targets and cancer types.

Some of these examples are already being evaluated in early stage studies in the clinic, while others have gone through their paces in terms of optimising performance and are about to head in this direction…

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