Not in San Diego: We took a close look at the potential for targeting gamma delta (𝞬𝝳) T cells early last year in an extended mini-series looking at the landscape including some of the early companies leading the way in this niche.
Since then there’s been a raft of company related announcements and collaborations in recent months, highlighting the ongoing interest in this field.
In this post, it’s time to revisit the original landscape (link), as well as explore how well some of the biotech companies who are active in this space are navigating the R&D roller coaster.
We will also be discussing recent data presented at the AACR20 virtual meetings.
So what did we learn about gamma delta T Cell therapies at AACR20 – who stands out from the increasingly crowded pack?
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Not-in-San Diego: The second part of the 2020 virtual annual meeting of the American Association for Cancer Research (AACR VM2) is over, and now the fun part of looking at some of the key data presented commences.
If you listened in to some of the sessions live like BSB did then you would have heard many of the chairs say how surprised they were to have 1,200 to 1,500 or more people listening live – AACR are to be congratulated on promoting access to science from around the world.
We all miss the personal interaction of a meeting but given the high cost of attending an annual conference, a virtual meeting does promote the democratization of science, and we are all for that. Given the ongoing uncertainties around the control of Covid–19, with all the travel and large crowds involved, it remains uncertain when we’ll all feel comfortable going to major conferences again.
One presentation that caught the attention of many at AACR VM2 including ourselves was data on a novel way to target IL–18 from the lab of Dr Aaron Ring (Yale), which was presented by his postdoc, Dr Ting Zhou at the meeting. A paper was also published simultaneously in Nature last week.
We’ve been following Dr Ring’s work on IL–18 for some time so it was good to finally see it published.
As part of our ongoing AACR20 coverage, Dr Ring kindly spoke to BSB to explain how his research led to the discovery of a novel way to target IL–18 for cancer immunotherapy as well as the plans to translate this into the clinic through a spin-off company, Simcha Therapeutics.
Will this novel way of targeting IL–18 be a winner? We take a closer look in this post.
To learn more from our oncology analysis and get a heads up on insights and commentary emerging from the second AACR meeting, subscribers can log-in or you can click to gain access to BSB Premium Content.
It’s time for another landscape review of a particular class of drugs in early development.
Here we take an in-depth look at the emerging SERD landscape in ER+ metastatic breast cancer. There’s a lot going on the ER+HER2- niche these days after a bit of a lull once we saw the CDK4/6 inhibitors approved so it’s a good opportunity for some extended colour commentary on what could become a hot area in oncology over the next couple of years.
Overcoming or delaying the onset of therapeutic resistance is going to be important, but how do we go about achieving this?
Historically we have seen some success in inhibiting the activity of the estrogen receptor (ER) as a driver of oncogenic activity, but what if we could degrade the aberrant protein instead? Would this approach yield some further benefits for people with advanced breast cancer?
There are quite a few companies, big and small, involved in this space so there’s still much to play for, especially in terms of figuring out what the ideal drug should look like and which combinations might be most useful. We also highlight key upcoming conference presentations to watch out for – hint: there’s quite a lot of them!
To learn more from our oncology analysis and get a heads up on insights and commentary emerging from the ASCO and second AACR virtual meetings, subscribers can log-in or you can click to gain access to BSB Premium Content.
Time for some additional colour commentary!
There has been some incredibly intense interest surrounding TIGIT as a new therapeutic target in oncology of late, to the point where some observers have been wildly claiming this is the new universal checkpoint everyone has been waiting for.
But is it?
It’s early days yet with little data presented from people with cancer, so at this point it could well be a bit of a stretch to find another anti-PD–1/PD-L1 equivalent, but this doesn’t mean there isn’t utility in seeing clinical activity in some tumour types, far from it.
In our latest post, we take a look at what’s coming up in the TIGIT niche, along with an interview from a company active in this niche.
What do the company have to say and how do they see this panning out?
To learn more from our oncology analysis and get a heads up on insights and commentary on a new checkpoint target called TIGIT subscribers can log-in or you can click to gain access to BSB Premium Content.
The American Association for Cancer Research (AACR) is to be congratulated on turning their annual in-person meeting into a virtual meeting at short notice.
With over 60,000 registered attendees, the meeting is a success and has set the standard for others to follow this year. While we all miss the opportunity to meet and network in-person, a virtual meeting does democratize access to science for scientists and researchers who can’t afford to travel or attend every year and we hope that live-streaming will continue in 2021 and beyond.
Since the sessions are available to watch for free on demand, we’re not repeating the data but like a postcard are instead focusing on what stood out for us, adding some pertinent commentary or context, as well some of our key take homes from a cancer new product development perspective.
Whether you agree, disagree, or thought differently about the presentations, we’re here to provoke thinking and critical discussion.
In this latest postcard from AACR20, we’re focusing on highlights from the adoptive cell therapy session taking place earlier today.
To learn more from our oncology analysis and get a heads up on insights and commentary emerging from the first annual AACR virtual meeting subscribers can log-in or you can click to gain access to BSB Premium Content.