Upregulation of ligands and receptors provides handy targets for antibodies and ADCs

Anyone who has been casually following oncology R&D over the last five years might be forgiven for thinking the gold rush and panning for nuggets in IO might have overtaken company interest in targeted therapies, whether they be small molecules, antibodies, or ADCs.

As hematologic malignancies evolve, proteins are upregulated on the surface of the cancer cells, providing a variety of novel targets to aim at therapeutically.

For those in the know, however, the quality of research in the targeted niche remains at a very high level with some serious research going on behind the scenes in terms of novel targets, focused clinical developments (i.e. not treating a targeted agent in an untargeted fashion), and even enhanced design of next generation molecules coming to the fore…

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