Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Cancer Immunotherapy

Posts tagged ‘JPM17’

We’re kicking off the first in a mini-series of expert interviews from the 2016 San Antonio Breast Cancer Symposium #SABCS16 with a leading researcher who has discovered a first-in-class compound that shows preclinical promise in several cancers including multi-drug resistant metastatic breast cancer.

It has a novel mechanism of action: 

“Interestingly, it was the only molecule, out of the 150,000 we screened that seemed to work through this pathway.”

To go from “bench to bedside,” and take this drug into the clinic now requires funding beyond what academia can provide.

If you’re at #JPM17 and into early stage VC funding or are in pharma/biotech business development BD&L and are on the look out for an innovative new licensing/investment deal, this post is for you.

What makes this a great story is I heard that one “missing piece of the jigsaw” in working out the pathway through which the drug worked came from unrelated research presented at a seminar on wound healing in zebrafish!

As a 2013 article by Robin McKie in The Observer notes, zebrafish (Danio rerio) share 70% of our genes, which makes them pretty cool research models. They are also transparent.

Hearing this anecdote reminded me of my conversation with Dr William Pao that you can hear on Episode 3 of the Novel Targets Podcast where he astutely said:

 “You never know where things are going to lead, you just have to be able to take advantage of them.”

That could also be a metaphor for life.

Science is about making sense of connections and patterns, which is why funding of basic science is so important. A piece of work by one researcher can unlock a breakthrough by another in a totally unrelated area.

While I was doing this SABCS16 interview, I was also reminded of the story behind the development of enzalutamide, and how AACR past-president Dr Charles Sawyers pitched his UCLA drug discovery work to several major pharma companies, without success, until Dr David Hung at Medivation took the risk… and the rest is history.

What makes that story so surprising is at the time Dr Sawyers already had a track record of success with his work on the development of imatinib!

It was a privilege to talk with a senior scientist at #SABCS16 who has thought outside of the box, made scientific connections, and in the process developed a new drug that shows exciting preclinical promise.

Improving the outcome for cancer patients requires the translation of basic science into new products that enter clinical trials.

I do hope funding will be forthcoming to move this first-in-class drug into the clinic so that’s its potential can be fully evaluated.

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If you’re at #JPM17, it’s a great time to buy a sub to BSB and put it on your expenses!

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It’s Wednesday at the 2017 JP Morgan Healthcare Conference and the last full day of the meeting. 

SF Streetcar at Pine StIt’s also our last day for a rolling blog; we hope you’ve enjoyed our coverage and commentary this year.

If you want to catch up on what we’ve written about, do check out our posts form Day 1 (Link) and Day 2 of JPM17 (Link).

Yesterday also included some thoughts on the latest Merck pembrolizumab filing announcement in 1L NSCLC, which has certainly had a dramatic impact on the market, even for big pharma (MRK +$4.9B, BMY -$3.3B).

Companies we’ve covered so far include: Celgene, Incyte, Seattle Genetics, Clovis, Puma, BMS, Five Prime, Nektar, Juno and others.

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It’s Tuesday at the 2017 JP Morgan Healthcare conference in San Francisco.

San Francisco Streetcar in RainEach day of #JPM17 we’re doing a rolling blog post which we’re updating throughout the day with commentary and insights on the company presentations we’re covering.

While we’re not giving a blow-by-blow account, many companies have the slides readily available, we will be commenting on noteworthy news, and what we learn about pharma/biotech corporate strategy going into 2017.

For those of you who like to catch up with the final summary of each day’s highlights, you can read our post around Day 1 here (Link).

Yesterday we also published a thought leader interview we did with Dr Stephan Grupp, Director of the Cancer Immunotherapy Program at CHOP about some of the latest CAR T cell data and emerging issues we heard at #ASH16 last month (Link).  Do check it out!

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It’s Day 1 of the 2017 JP Morgan Healthcare Conference in San Francisco…

San Francisco StreetcarDespite the travel challenges associated with the cold weather hitting much of the United States, many have made [or are in the process of making] the “pilgrimage” to hear leading pharma and emerging biotech companies lay out their strategy and goals for the coming year.

Every company that presents at #JPM17 has made their New Year’s resolutions… and like the ones we make personally, some will work out, while others will fall short.

In light of the success of our rolling blog from last years’ JPM conference (link to #JPM16 coverage), we’ve decided to repeat the concept again this year. Throughout the day (schedule permitting) we’ll be updating the post with commentary around news that catches our attention.

If you want to follow along yourself and listen to the company presentations, here’s the link to the JPM17 webcasts and conference agenda (link).

As an aside, in our coverage we will be using JPM followed by the last two digits of the year of the meeting i.e. #JPM17, last year it was #JPM16. This is how the “BioTwitter” community commonly refers to the meeting, and we will be continuing that tradition, notwithstanding the fact that JP Morgan have announced the “official” Twitter hashtag is awkward and long winded #JPMHC35.

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