Time to unlock some novel IO targets?
Continuing our latest four part mini-series, this one is on novel targets and agents and we now turn our attention to immuno-oncology in the last two articles pertaining to this particular topic.
You can read the first two articles on targeted therapies here and here.
For the avoidance of any doubt, this latest review is not about T cells, far from it.
Instead we cover six different areas, most of which are related or integrated in some shape of form.
There’s a lot of promising new science now coming out to help us better understand the underlying biology and also think out of the box about ways to enhance or improve on existing research.
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After the snow flurry in Atlanta that induced much panic and minor frustration in equal measure after the trials and tribulations of a tiring travel day with delays and cancellations galore. Then you see attendees waking up to a veritable winter wonderland in the south:
Meanwhile, things soon settled down somewhat and life got back to normal at the American Society of Hematology (ASH), as this quick time lapse that 3NT recorded showed down the main thoroughfare :
It’s time for our annual meeting daily highlights and lowlights because after all, oncology R&D is not a rose tinted garden and thus not every session or compound you highlight pre-conference will turn out as expected and sometimes, there are pleasant surprises that few see coming so you could end up at sixes and sevens if you don’t watch out…
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In the sixth Preview relating to the annual meeting at #AACR17, we take a closer look at an immuno-oncology topic that we are likely to see and hear more about over the next couple of years.
Indeed, I’ve followed some cancer conferences where it wasn’t even mentioned, much to my surprise. It should be, it’s likely going to be both needed and receive a lot of attention over the next few years.
What we need is a bridge for greater success. What does that look like though and how do we go about achieving it?
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While in Marseille for the scientific meeting to celebrate the 40th anniversary of the Centre d’Immunologie de Marseille-Luminy (CIML), I had the pleasure to interview Hervé Brailly PhD, the CEO of Innate Pharma, a leading biotech company in the Marseille Immunopôle.
Innate Pharma (@InnatePharma) was founded in 1999 by six immunologists: Hervé Brailly, Eric Vivier, Marc Bonneville, Alessandro Moretta, Jean-Jacques Fournié and Francois Romagné.
Yesterday’s blog post on “Why Target the Innate Immune System? An interview with Eric Vivier” sets the scene for today’s post.
Innate Pharma, as the name suggests, has pioneered targeting the innate immune system. The company has leveraged the research undertaken at CIML by Professor Vivier and others in the field of innate immunity.
Innate is leading the way in immuno-oncology by targeting checkpoint receptors on natural killer (NK) cells. In 2011 Innate signed a licensing deal with Bristol-Myers Squibb for the development and potential commercialization of lirilumab.
In a recent financial report (link to Sept 8 press release) the company announced that several clinical trials would read-out in the forthcoming months.
Without disclosing any material non-public information, Dr Brailly kindly spoke with BSB and talked about his vision for Innate, what data readouts we are expecting, and the inflexion point the company is now at.
This post was updated on Feb 6, 2017 with the announcement that the EFFIKIR AML trial failed to meet it’s primary endpoint.
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