Will there be a whirlwind of new targets emerging?
It’s time to get back to basics – and also our roots – with a look at potential new targets and approaches that could emerge in the future.
Successful oncology new product development isn’t about the latest shiny new thing that’s in fashion, or everyone is following now, but is much more about the long term game of understanding the biology of disease, finding the gaps (opportunities) and developing new compounds faster than everyone else.
If truly we want to create blue ocean strategies then it begins with the science and builds out from there.
On the slate today we have four areas of interest that could yield new products or indications in the future.
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San Francisco – Yesterday at the ASCO Genitourinary Symposium, Dr Kim Chi noted that emerging data suggests that ctDNA appears to give better picture of tumour mutations than biopsy and can also monitor tumour load. This is an encouraging development that may facilitate increased use of the diagnostic as a helpful biomarker of response in clinical trials with immune checkpoint blockade.
We also know that prostate cancer sits firmly in the middle of the now famous Alexandrov and colleagues tumour mutation burden (TMB) analysis, but what factors are important in our understanding of the underlying biology of the disease?
There are many inhibitory factors exerted on the tumour microenvironment and thase may vary not only by tumour type e.g. renal cell carcinoma may have a greater influence from VEGF than prostate cancer, but also in individual patients.
With this in mind, I wanted to explore some new combination data being presented at the meeting, as well as look aspirationally to some potential combinations currently in development that may have escaped many people’s attention.
In this post, we take a look at current and future implications that keen observers should be watching out for…
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