In the last post from SABCS, we looked at what’s new on the translational front with the MYC oncogene in terms of breast cancer.
This time around we turn our attention to other targets and subsets of interest, which don’t involve immunotherapy – more on the latter in a separate article.
Today’s featured image is inspired by my dear friend Jody Schoger and Lisa Adams, who inspired us to find a little beauty in the world each day, no matter how hard it might seem. 2015 was very bad year for losing wonderful BioTwitter chums in the breast cancer community – they may be gone, but never forgotten 🙁
In particular, we highlight new developments in four key areas of interest, with some intriguing observations to discuss…
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This weekend in the oncology conference calendar saw the ESMO Breast meeting take place.
The event was originally planned as a live event in Berlin – sadly with the pandemic it ended up as a virtual meeting on Central European time, yet you can still imagine the Berlin bear welcoming everyone regardless of format!
This is a good time to take off we we left off last week with our SERD landscape review since there was some new clinical data presented in this niche, as well as segue to the ASCO meeting on Friday where other companies will also be showcasing their early data.
Aside from SERDs, there were plenty of other highlights and commentary to consider in advanced breast cancer.
Here we explore some of the findings and offer some context for at least one commercial showdown…
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San Antonio River Walk
San Antonio – It’s time to switch horses and focus on the annual meeting of the San Antonio Breast Cancer Symposium (SABCS).
There have been many exciting developments in the HER2-positive niche and this meeting is no different in terms of new agents with promising (and some not so promising) to discuss.
We take a look at the tucatinib and trastuzumab deruxtecan data and put them in context because there are some nuances involved in both that need careful consideration.
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It’s time for an update on TLRs – Toll-like receptors – as a way of igniting the fire of the tumour microenvironment. We have repeatedly seen how only a minority of patients respond to immune checkpoint blockade and how there are a multitude of reasons for why this is the case.
In some patients, the immune response is stalled in some way, thereby necessitating a jumpstart. Reasons for this might include lack of recognition of the cancer cells, poor antigen presentation, immunosuppression, immune escape and so on.
In other words, we need more firepower and novel rational combination approaches to stimulating both the innate and the adaptive immune systems in order to derive a more potent and durable response in a larger number of patients. That’s where TLR agonists come in.
As always in oncology R&D, there have been some failures already but we have also seen more promising compounds emerge as well as improved understanding of the science behind the immune system defects that occur in cancer.
Armed with this knowledge, will the current crop of molecules produce better results? To find out, we took at look at some of the recently available data and also interviewed an emerging new company in this niche to learn more about their quite different approach to the challenges…
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