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Shining a beacon

Our take on data from half a dozen key trials at ASCO GI24

January 24, 2024
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A oncology biotech to pay attention to

A look at an emerging early stage product which is looking intriguing

January 22, 2024
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Will targeting KRAS G12D prove more successful than G12C?

Going beyond the first past the post syndrome...

January 25, 2023
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Cracking the code to the MYC oncogene

A novel approach to targeting an intractable oncogene

January 23, 2023
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Doubling down on modest data

A look at some recent phase 2 data in the KRAS niche in the context of the broader landscape

January 27, 2022
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Important changes to watch out for in the GI cancer landscape

Preview of what to watch out for at ASCO GI22

January 18, 2022
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New developments in GI cancers from ASCO GI 2020

A report card on important trial updates across gastric, pancreatic, liver, and colorectal cancers at ASCO GI 2020.

January 27, 2020
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The Yin and Yang of biomarkers in cancer research

Some examples of potentially useful biomarker inclusion in early oncology trials

January 22, 2019
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Insights from the ASCO GI19 conference

What to watch out for at the ASCO GI19 conference in San Francisco

January 17, 2019
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Immune Landscape of Pancreatic Cancer

A look at where we are in pancreatic cancer and how the landscape has evolved of late...

January 25, 2018
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ASCO GI18 Preview

A look at 8 key abstracts being presented at #GI18 in San Francisco this week.

January 17, 2018
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ASCO GI17 Gems from the Poster Hall

A look at gems from the #GI17 poster halls or molecules destined for Dog Drug Heaven?

January 27, 2017
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Is 2017 the Year of the Cancer Vaccine?

A look at another approach for turning cold into hot (or warmer) tumours with cancer vaccines.

February 21, 2017
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New developments in advanced colorectal cancer

A couple of trials at ASCO #GI17 look promising in terms of trial design with encouraging implications for the future in metastatic colorectal cancer.

January 26, 2017
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Will nivolumab make an impact in gastric cancer?

Will gastric cancer be one of the next indications for nivolumab?

January 25, 2017
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Update on Targeted therapies and Immunotherapies in Gastric Cancer

Who will move the needle in gastric and oesophageal cancers - targeted therapies or checkpoint immunoherapies?

January 27, 2016
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Will pembrolizumab extend its activity in GI cancers?

Will checkpoint blockade be effective in multiple GI cancers and if so, why?

January 25, 2016
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Overcoming acquired resistance to EGFR therapies in colorectal cancer

Which new combinations could improve outcomes for colon cancer patients receiving EGFR therapies by overcoming acquired resistance?

February 19, 2015
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Molecular Characterisation of Colorectal Cancer

We've seen very little real progress in colorectal cancer beyond incremental improvements since Erbitux and Avastin were approved a decade ago. Are we on the threshold of a new paradigm shift?

February 17, 2015
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Overcoming acquired resistance to BRAF in colorectal cancer

Patients with BRAF driven colon cancer don't do as well as those with melanoma: how can we overcome acquired resistance to RAF treatment?

February 13, 2015
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Precision medicine in advanced colorectal cancer

If we truly want to see a more precision medicine approach evolve then we have to first find the oncogenic drivers. At ASCO GI one study in particular caught my eye and attention, but you won’t find it written up in the medical lay press and it’s not that obvious unless you know what you’re looking for.

January 20, 2015
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ASCO GI Keynote: The future of Immunotherapy is Combinations

“We are at beginning of a REVOLUTION in immunotherapy,” said Elizabeth M. Jaffee, MD at the start of American Society of Clinical Oncology GastroIntestinal (ASCO GI) symposium keynote lecture on Immunologic Treatments for GI Cancers.

January 21, 2014
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ASCO GI 2014 Preview: Pancreatic and Gastric Cancer

Preview of some of the key data being presented at ASCO GI in San Francisco this month.

January 3, 2014