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Will bromodomain inhibitors and PROTACs make an impact?

A look at BET-bromodomain inhibitors, PROTACs, stapled proteins and more on MYC

September 4, 2019
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Can a new class of agents therapeutically target the MYC or RAS oncogenes?

How do we go about therapeutically targeting deep protein-protein interactions that can cause aberrant cancer activity? Here's one novel approach in early development...

September 3, 2019
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Gerard Evan discusses inflammation and immune suppression in cancer

How do mission critical oncogenes cooperate and act in concert in cancer?

August 30, 2019
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Why does Myc drive out T cells?

If we want to be able to drug oncogenes such as MYC then we need to figure out how they work and function to find the achilles heel

August 29, 2019
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Dancing with proteins

Proteins change shape, both temporally and also in response to different conditions. Can we use this information to develop novel cancer therapeutics? One company is exploring ways of achieving this.

May 6, 2019
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How understanding patient tumours can help us with future IO trials

Looking under the hood to find biomarkers of response and outcomes, ,

June 10, 2019
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On the interaction between transcription factors and the immune system

A potential role for epigenetic therapies in straddling the divide between transcription factors and the immune system...

August 26, 2019
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ASH Preview 2 – Developmental Therapeutics

A look at a selection of promising Developmental Therapeutics abstracts from ASH17 - what's in store this year?

November 29, 2017
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The BET Bromodomain Landscape in Cancer Research

The bromodomain market has exploded in recent years with many more agents in the development. Are they all the same though?

May 26, 2016
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Super Enhancers – what are they and why do they matter in cancer research?

Understanding the regulatory circuitry that controls cell state and differentiation may turn out to be groundbreaking research that changes the way we think about targeting and treating cancer.

April 14, 2014
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Through the window on the MYC oncogene

What can we learn about the MYC transcription factor and oncogene in order to turn it into a viable target in oncology R&D?

August 21, 2019
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AMG 596 EGFRvIII BiTE

A look at Amgen’s early oncology pipeline

Amgen have a large early phase 1 oncology pipeline including bispecifics, BiTEs, a CAR and small molecules. What can we learn from recent data presented?

July 18, 2019
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Targeting MYC – the undruggable protein – or is it?

Targeting MYC and bromodomains is an emerging area of research as we learn more about super enhancer transcription factor clusters around oncogenes that drive cancer.

May 26, 2015