Saw this arrangement in a local orchid garden, which reminded me of the blobs used to illustrate E3 ligase – protein complexes

In the first of our new season AACR Preview series, we continue to explore what’s happening in the protein degradation and molecular glue niche.

Yes, it’s still early days and there’s much we don’t know but it should be useful to follow the developments and see what can be learned.

Perhaps a few observers might be surprised at the sheer range of targets being evaluated in R&D pipelines since some of these are definitely not of the every day kitchen sink kind of variety.  There is no doubt in my mind some will be easier or much harder than others, but what is intriguing is the depth of the details which are starting to emerge of late.

So what’s in store and which abstracts stood out this year in this niche?

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