Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Immunotherapy

About MaverickNY

Here are my most recent posts

Posts by MaverickNY

Which early stage agents will stand out or crash at ESMO22?

In part one of our ESMO preview series on developmental therapeutics last week we highlighted some key immunotherapy presentations to watch out for.

This time around it’s the turn of early stage targeted therapies to be put in the spotlight.

Traditionally these have been a particular strength on the ESMO programme, although they have been rather over-shadowed over the last five years or so by the rise of immunotherapy this and that.

This year heralded a new crop of agents to evaluate, as well as a bunch of compounds with updated expansion phase or phase 2 readouts at the recommended dose, which should give us a much better idea of how well they are performing.

Not all of these selections will make it to phase 3, however, and will likely be destined for the dreaded dog drug heaven although the good news is some are looking pretty encouraging thus far…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

In our latest ESMO conference preview it’s time to pick some early stage immunotherapy highlights to watch out for.

Which ones look promising, which might be duds?

You can’t always tell from abstract titles, even if the trial has been selected for oral presentation so right now we’re flying by the seat of our pants somewhat if the top line result hasn’t been formally announced yet.

Our selections include a variety of different modalities such as monoclonal antibodies, cell therapies, bispecific antibodies, fusion proteins, and even small molecules across a wide range of targets…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Gastronomic delicacies in Paris

In our second ESMO 2022 Preview we take a look at some of the key trials being presented in gastrointestinal cancers and highlight what to watch out for on this front.

While a few readers will no doubt be keen to skip to the KRAS section to learn more about sotorasib and adagrasib in colorectal cancer, make no mistake there’s plenty going on in new product development in several other GI cancers too, both with targeted therapies as well as immunotherapies.

Curious to learn more?

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Time to make your selections!

This year seems to be going all to quickly as we have arrived in time for the annual ESMO Preview series.

This year we have a lot of topics to cover from a review of various solid tumour types, novel targets and developmental therapeutics, hematologic malignancies, as well as various IO and cell therapy related readouts.

As always, the goal of our previews is to not only provide some context for what to expect, but also to highlight potential success and failures since not all of the trials have been headlined by the companies concerned.

It’s all to easy to forget agents in the same class of therapeutics can produce quite different outcomes despite similarly looking trial designs, as we will find out…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Linie 30 Florisdorf, Vienna

With all the frequent attention on lung cancer of late – mostly on the most common form, non-small cell lung cancer – it’s easy to forget small cell lung cancer (SCLC) in the rush to highlight new developments.

It’s time to talk turkey about old and new agents in the quest to improve outcomes for people with this dismal disease.

The good news is there are also a raft of scientific developments emerging, which may potentially help us better identify discrete subsets and enable the matching of appropriate regimens to the underlying biology.

At the World Conference in Lung Cancer this week in Vienna we’ve been following the numerous trials (and tribulations!) of progress in this niche, with a look at several key readouts through the lens of a thoracic lung cancer specialist.

What does he have to say and where are things heading next for the field?

To find out more, check out the interview below…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Oper Wien

It’s time for our second post on WCLC22, which also happens to be on the hot KRAS G12C niche.

The first part analysing the sotorasib plus checkpoint combo was posted here for anyone who missed it.

This time around we’re going to explore different combinations and look at some of the fast-follower agents coming up on the rails.

After all, this is more than a two-horse race where the winner isn’t necessarily the first past the post, but rather the one either with the widest therapeutic window or who figures out the optimal combination partners.

Curious to learn more?  Check it out…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Münze Österreich

The World Conference on Lung Cancer (WCLC) is underway in Vienna, and for those who arrived early, Friday was the hottest day of the year (37°C) so far!

Is the data at the meeting as hot as the summer weather?

Companies undertake drug development with the best of intentions, but there comes a moment in time where you have to take stock of what exactly is the data is telling you?

Did we experience an epiphany or turning point at WCLC for KRAS G12C inhibitors in lung cancer? Or is there still a way to be travelled on the road to Damascus?

In this latest post we take a look at some key data presented during the meeting and what it means for those in this space.

It’s a story we’ve been following for some time, and as always, there are nuances to be had, because it’s far from black or white…

To continue reading our latest discussion on oncology new product development plus commentary and analysis, BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

 

Whenever I think of ‘salad days’ – a Shakespearean expression referring to a youthful time, a period of carefree innocence and idealism – the idyllic Indian summer of 1976 comes to mind when the summer actually meant more than merely a few hours of sunshine for a couple of days in England, rather than days of rain and inclement weather cancelling much anticipated leisure events.

Of course, with warm lazy days one also remembers the opportunity for voracious reading, thinking, staring up watching the clouds while letting thoughts and ideas coalesce in the background.

Science is a bit like this too, coupled with great ideas coming out of asking pertinent big picture or provocative why and how questions.

There has been a crop of excellent research published this year including a nice batch of studies on a diverse range of cancer related topics, which may have important considerations for future pipeline development or novel combination studies.

Obviously one can’t write about them all, so we picked half a dozen to pique our readers interest…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Degrading proteins, block by block

Our KRAS review last week included a lot of different inhibitor compounds (well over 30 of them), illustrating just how complex this niche is rapidly becoming, with only a brief mention of targeted protein degrader (TPD) compounds since these are much further behind their small molecule inhibitor counterparts.

Since then there’s been some more big picture talks or three about the TPD space, which are well worth discussing, as well as a flurry of relevant questions from BSB readers to be addressed.

Here we discuss the KRAS niche in the context of protein degraders and look at the promise and some of the inherent challenges faced…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

It seems astonishing to realise only a couple of years ago KRAS was considered undruggable intractable and here we are, not only with one drug approved, another filed and veritable long list of fast followers, but a whole ecosystem of different agents vying for a place at the table.

The wonderful news is we are starting to think more broadly about life beyond G12C mutations, not only with different combinatorial approaches, but also also in the context of how to tackle other related mutations as well.

Here, we wanted to explore the evolving universe more broadly and assess criticality as well as applicability – which agents might shine tomorrow if clinical data turn out positive?  The simple answer is more than you know.

So just who are the rising stars in this emerging landscape and what can we learn about them?

Be warned in advance – this is one of our longest and most comprehensive reviews on BSB with over 30 compounds highlighted in different guises, so grab a cup of Joe and be prepared to come with an open mind…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

error: Content is protected !!