Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Cancer Immunotherapy

Posts tagged ‘abemaciclib’

Are the lions roaring in Chicago?

In our latest coverage from the annual meeting at ASCO we explore and discuss some of the highlights from Day 1 of the meeting.

It used to be Friday was reserved for the educational events and Saturday was the start of various oral sessions.

Increasingly, the meeting has now become so jam packed we now see a number of tumour type oral sessions on Friday and a wave of posters on Saturday.

We asked ourselves what were the controversies and findings that stood out from pack and why do they matter?

To continue reading our latest highlights on oncology new product development including commentary and analysis, BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

There’s no ASCO meeting without the Bean

After a long wait and much anticipation, the NATALEE late breaker results are finally in!

In this adjuvant breast cancer study involving Stage II/III disease, ribociclib was added to standard endocrine therapy (ET).

We have already seen the equivalent readouts from Pfizer and Lilly, with very different outcomes.

The Novartis trial followed same the positive trend as the Lilly study, but what about the subtleties and nuances involved?

Here we put the NATALEE trial through its paces and discuss the ins and outs relative to the niche…

To continue reading our latest highlights on oncology new product development including commentary and analysis, BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Some ASCO23 abstracts to grab your attention!

As we head into the annual meeting of the American Society of Clinical Oncology (ASCO), it’s time to review some key abstracts which may grab your attention.

Of course not all of these will be positive in nature, yet some are already planned for phase 3 investigation on the basis of some rather skimpy early data…

While at the other end of the extreme are some important data largely under many people’s radar.

Here we highlight a dozen examples of what’s coming this weekend, explain what to watch out for and offer some important caveats or questions to think about.

To continue reading our latest highlights on oncology new product development including commentary and analysis, BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

A familiar Paris Metro sign

To get around Paris efficiently, we might start off at one particular Metro station and need to change lines or direction several times in order to arrive at our destination on the other side of the city.

Similarly, I’ve often wondered if repeating endocrine or hormonal therapies in breast or prostate cancers is a big like staying on the same line and never getting to where we really need to go.

Just as CDK4/6 inhibitors revolutionised the treatment of HR+/HER2- advanced breast cancer by allowing physicians to target a different pathway or axis, should we be rethinking new approaches to an old problem?

In our latest story from the ESMO22 conference, we explore some of the emerging evidence…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Time to make your selections!

This year seems to be going all to quickly as we have arrived in time for the annual ESMO Preview series.

This year we have a lot of topics to cover from a review of various solid tumour types, novel targets and developmental therapeutics, hematologic malignancies, as well as various IO and cell therapy related readouts.

As always, the goal of our previews is to not only provide some context for what to expect, but also to highlight potential success and failures since not all of the trials have been headlined by the companies concerned.

It’s all to easy to forget agents in the same class of therapeutics can produce quite different outcomes despite similarly looking trial designs, as we will find out…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

There’s no ASCO meeting without the Bean

There’s always a parable or two to be had at ASCO and this year was no different, especially in the breast cancer space where there were plenty of phase 2 and 3 trials to discuss as well as offer commentary on the various findings.

Not all of the results were standouts though, with some creating controversy in the process.

Here, we take a look at some examples and put them in context…

To continue reading our latest discussion on oncology new product development plus commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

 

 

In the last post from SABCS, we looked at what’s new on the translational front with the MYC oncogene in terms of breast cancer.

This time around we turn our attention to other targets and subsets of interest, which don’t involve immunotherapy – more on the latter in a separate article.

Today’s featured image is inspired by my dear friend Jody Schoger and Lisa Adams, who inspired us to find a little beauty in the world each day, no matter how hard it might seem.  2015 was very bad year for losing wonderful BioTwitter chums in the breast cancer community – they may be gone, but never forgotten 🙁

In particular, we highlight new developments in four key areas of interest, with some intriguing observations to discuss…

To learn more from our oncology analysis and get a heads up on the latest insights and commentary pertaining to the SABCS meeting, subscribers can log-in or you can click to gain access to BSB Premium Content.

This content is restricted to subscribers

One thing I really miss from attending live conferences – aside from catching up with people in person – is “the living like a local” experience. Last time I was in Madrid, for example, there was this fishmonger (pescaderia) just a block down from the rented apartment. They were only open in the mornings, so you could dash down the hill, quickly nab some fresh produce, refrigerate it and have something nice to look forward to for dinner with a glass of wine at the end of a tiring day while writing up the highlights…

The image also offers another analogy – do some data presented at a meeting end up, well, a bit fishy on closer examination or reflection despite much of the hype enthused or extolled by others?

At the ESMO20 virtual Congress, we covered a tremendous amount of details from the data during both the daily highlights as well as the previews exploring what to watch out in the run-up to the event.  You can find all those reviews here.

There are always some surprises in store, however, both good and bad.  There’s also layers of obfuscation going on to consider in the form of cheerleading from companies, investigators, or stock holders, which may add positive spin on what is essentially so-so data, cases where great data goes largely ignored for whatever reason, or important lessons to be learned from failure.

In this wrap-up post, we take a sharp look at the ESMO20 winners, losers, and risers from a contrarian’s perspective…

To learn more from our oncology analysis and get a heads up on the latest insights and commentary pertaining to ESMO20 virtual congress, subscribers can log-in or you can click to gain access to BSB Premium Content.

This content is restricted to subscribers

A typical scene from ESMO 2019

Not in Madrid – Is it really only a year ago many of us were frantically dashing around at ESMO last year navigating crowded corridors, long queues for coffee, hunting down the last empty seat in jam packed halls, not to mention feeling the anticipation build for key data being presented in the Presidential sessions?

There are undoubtedly many advantages to virtual digital meetings, aside from the broader access for more people it provides and being able to see the slides unimpeded, yet it must be confessed the things I miss the most are the social interactions and catching up with people and their lives, however brief a moment it may be amongst the hurly burly of 20,000 other souls.

The cultural things we take for granted are often the very essence of what we miss most when they’re no longer obtainable.

Who truly would have guessed our world could be completely upended by the unexpected events of a global pandemic since then? In some ways, it has changed our perception of both time and space.

We have also seen some surprising changes in the fortunes of various clinical trials; some completely rational and predictable, others quite the opposite, as we learned yesterday in a very topsy turvy kind of way.

It’s time to discuss and review the highlights – and lowlights – from ESMO20 Sunday in part 2 of our daily coverage…

To learn more from our oncology analysis and get a heads up on insights and commentary pertaining to ESMO 2020, subscribers can log-in or you can click to gain access to BSB Premium Content.

This content is restricted to subscribers

Not in Madrid – with the global pandemic continuing to exert a significant effect on the cancer conference season, the annual meetings continue apace virtually.

Plaza de Cibeles, Madrid

For this year’s ESMO meeting we have already covered immunotherapies, both early and late stage pipeline highlights and now it’s time to explore what to watch out for over the weekend on the early to mid stage targeted therapy front.

The good news is there is some potentially practice changing data being presented, as well as some novel approaches in preclinical development emerging. These should be hitting the clinic in the near to medium term future.  On the other extreme is the more common problem whereby a few agents are showing signs of not holding up to their early promise/hype.

Let’s now take a look at what we can learn in the fourth and final ESMO Preview for 2020…

To learn more from our oncology analysis and get a heads up on insights and commentary pertaining to ESMO 2020, subscribers can log-in or you can click to gain access to BSB Premium Content.

This content is restricted to subscribers

error: Content is protected !!