Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Immunotherapy

Posts tagged ‘TLR7/8’

There’s always a lot of time and attention focused around phase 3 clinical trial readouts at ASCO, but what about some of the hidden gems where we can learn quite a bit from earlier developments?

This is a two-part series this week where we go off the beaten track on the road less travelled to explore some novel approaches, which may or may not make an impact.

Don’t forget we can often learn as much from negative studies as we do from positive ones because they can teach us what not to do in terms of future design of anti-cancer therapies.

New product development is very much a process of Kaizen, or continuous improvement where we adapt both from what went less well as well as what worked really well.

This year’s ASCO data drop has some important lessons embedded within for those intrigued to dig deeper and pay attention to the finer details…

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Fans of Harry Potter, will no doubt be familiar with the Goblet of Fire (“La Coupe de Feu” in the French version) and how it was used to select the champions from three schools of magic who would compete against each other in a tournament.

The metaphor of fire is very apt when it comes to cancer immunotherapy, as we’re often seeking to either create or optimally target an inflamed tumour microenvironment.

In this post were looking at how prior research and an understanding of science can sometimes lead to an unexpected contender in the “Goblet of Fire” that is early stage cancer drug development. Could the contender end up as the new champion AKA standard of care?

As in the Harry Potter story, there are trials that have to be conducted and overcome along the way, and until the data reads out there is uncertainty as to how the story will end.

Intrigued? Do read on…

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National Harbor – Missing the Fall colours!

As we get into the final swing of the Fall cancer conference season, at SITC this weekend there was much to think about in terms of early stage oncology drug development.

Still, it did feel rather surreal not to be in Maryland at the Gaylord National Centre in National Harbor for a live meeting this year, especially considering this particular specialist IO meeting tends to be held in a small jam-packed hall with nary an empty seat to be had!

I thought it would be fun to focus on an area which is slowly receiving more attention, with at least one sub category actually beginning to look quite promising indeed…

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