Pathways to success with small molecule developments

It always amuses me when people describe the small molecule space in lymphomas as ‘neat and ordered’ when in reality, it is anything but…

After all, not all patients respond initially, some cannot tolerate the side effects, and additional mutations can be acquired in response to therapy inducing acquired resistance and sometimes more aggressive disease results.

How do we go about addressing all of these issues in order to improve outcomes further?

We can certainly get a few ideas from the early stage pipelines being evaluated, as well as from the kind of combination regimens currently being developed.  What do the results show?

Then there’s a raft of quite unrelated agents which might be competitive and could usurp existing approaches should they move earlier up in the treatment paradigm.  Plenty of Pharma execs have certainly been caught out in the past not keeping their eyes on the right eight ball.

In our latest ASH20 Preview we highlight a few intriguing abstracts to watch out for at the forthcoming meeting this weekend…

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