Novel strategies for addressing an intractable cancer target
Source: AlphaFold
In today’s post we’re going to discuss some new findings and explore important research published on different aspects of the same central target.
What can we learn, what are the implications, and what new developments are emerging in this niche?
You can clearly see from the Alphafold database representation of the protein structure (right), while the blue central section can be predicted with a high degree of confidence there is quite a bit on the spindly periphery with much less confidence. Does this impact our ability to drug the target?
Perhaps, but there is also much around the cell interactions and processes involved we don’t know either.
The good news is there are some intriguing new developments worthy of review and discussion…
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