Imagine a scenario… a symphony of therapeutic agents working in harmony, each contributing its part to achieve remission in even the most refractory hematologic malignancies. Yet, as with any great orchestra, a poorly tuned instrument – or in this case, a poorly considered combination – can disrupt the entire performance.

Bispecific T cell engagers have emerged as new virtuosos in cancer therapy especially in refractory settings involving hematologic malignancies such as lymphomas and myeloma, although their integration into combination regimens may be as challenging as it is promising.

Don’t be caught napping though!

In our latest ASH analysis, we’ll explore how some of these combinations perform, where they falter, and whether they can truly expand the therapeutic repertoire or simply shrink the index of possibilities.

In this review we will explore half a dozen different bispecifics when given in combination with an additional therapy to determine if:

  • They add anything to hematologic malignancies over what we would expect for monotherapy
  • Whether or not they shrink the therapeutic index
  • Whether anything else of note stood out (positive or negative)

If they fail on the first and negatively impact the second then they are highly unlikely to be a candidate for further clinical development!

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