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Pointed ironies: SERD wars, ADC hype, and what really works in breast cancer

ASCO Preview on Breast Cancer

May 5, 2026
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A study in regulatory conservatism versus clinical innovation

A review of camizestrant's upcoming ODAC meeting

April 30, 2026
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Bispecific ADCs and the conditions nobody is talking about

Challenges and limitations associated with bispecific ADCs

April 9, 2026
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After T-DXd: target, payload, or something else?

The recent debate around trastuzumab deruxtecan (T-DXd) resistance has quietly split into two camps:…

February 10, 2026
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SABCS25 Highlights – Reading between the slides

Review of 10 key early and late stage trials, including Relay and Scorpion's mutant selective PI3Kα inhibitors

December 17, 2025
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Building an ADC platform beyond the Topo-I crowd

The hunt for novel payloads for ADCs continues apace

November 17, 2025
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SITC25: Findings Worth Your Attention

SITC25 Roundup with some suprising findings to take note of

November 10, 2025
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A new KRAS G12D inhibitor finds its footing

Targeting KRAS G12D has already seen some shakeout – can the next generation agents prove successful?

October 28, 2025
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CrossBridge Bio and Chengdu Kanghong ratchet up the stakes

A look at emerging ADCs in many shapes and flavours, including dual and novel payload versions

October 24, 2025
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A bear thesis – why HARMONi-6 won’t replicate globally

The trouble with translating Chinese trials to Western populations

October 22, 2025
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Revenge of the Farnesyltransferase Inhibitors

A classic comeback story

October 20, 2025
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Another brick in the wall

New developments in metastatic and early stage breast cancer from Berlin

October 18, 2025
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Beyond the Biergarten: ESMO’s Unusually Productive Friday

Highlights and lowlights from Day 1 of ESMO25

October 17, 2025
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The next generation of cancer therapeutics at ESMO

A look at some early stage IO agents and small molecules coming down the pike

October 14, 2025
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Purple Cows at ESMO: six ADC trends worth watching

Standing out from the crowd – 6 ADC trends to watch out for at ESMO

October 9, 2025