Some reflections on success and failure of CAR-T cell therapy in AML

I can’t quite recall who first offered this sage advice; it might have been Michael Caine as he often comes up with excellent practical if pithy advice such as ‘use the difficulty’:

If you want to find the solution to a complex problem then turn the problem upside down.

This is a great idea because it offers an opportunity to look at things from an entirely different perspective with fresh eyes.

Some new clinical and translational data has recently been published where the researchers did exactly that and came up with some intriguing findings. The outcome of which could prove to be helpful in prospective clinical trials…

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