For over a decade, cell therapy in cancer has embraced a simple philosophy: maximum firepower to eliminate malignant cells.

As these powerful tools enter autoimmune disease trials, however, a fascinating evolution is underway as companies begin releasing research on their pipelines at conferences.

Are the data breathing fire – or even too much of it?

From the early groundbreaking lupus studies to more precision targeting tools coming through preclinical development, researchers are discovering that finesse may well trump force when it comes to treating chronic inflammatory conditions.

This shift – from indiscriminate B cell destruction to more selective targeting of disease-driving cells – could redefine how we reset dysfunctional immune systems.

New data from the American College of Rheumatology (ACR) meeting held this week in Washington DC showcases this transformation while highlighting innovative approaches under the radar, which may finally thread the needle between efficacy and safety.

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