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ASH24 Preview 1 – Captivating CAR-T cell Developments

What's hot amongst the up and coming CAR-T cell therapies in early development?

November 6, 2024
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An unexpected emerging onco landscape to watch out for

Which Thunderbirds are Go in this niche?!

October 22, 2024
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The Future of Fratricide-Resistant CAR-T Cell Therapy

Going beyond gene edited CARs

October 16, 2024
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Dramatic new paths being taken in autoimmune diseases

A smorgasbord of bispecifics and CAR-T cells for autoimmune diseases

October 1, 2024
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Decoding CD123 CAR-T cells in AML

Reflections on how to overcome hurdles associated with CAR-T cell resistance

September 27, 2024
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Pointing the way

Are there hideen treasures in Yokohama, Japan

August 12, 2024
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A Renaissance in Biomarkers at ASCO24

Teasing out relevant markers and learning more about what patients tumours are telling us is key

May 29, 2024
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A new dawn or the sunsetting of cytokines?

It's time to challenge our thinking on cytokines

May 24, 2024
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Is TGF-β making a comeback in cell therapy?

Will new developments in tackling cytokines fare better in the clinic than the first generation attempts?

May 13, 2024
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Wow I wished I’d thought of this!

It's beginning to look a lot like Christmas...

December 21, 2023
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Same Controller, Opposite Outcomes

The Yin and Yang of NK and T cells and how this can impact therapies

December 15, 2023
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Seeing the wood from the trees at ASH23

How a competitive landscape can change drastically over a short time

November 27, 2023
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Unveiling the science behind a new IO strategy

A look at the potential missing piece in making bispecifics even better

November 10, 2023
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SITC23 Scorecard for emerging novel IO therapies

W2W4 at SITC23 - 10 emerging areas to pay attention to in IO

November 6, 2023
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Pointing the IO way

Eight key areas to watch out for at SITC 2023!

October 27, 2023
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A look at early stage trials debuting at ASCO23

What do three phase 1 and one phase 2 trials tell us about future development?

June 5, 2023
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What will novel CAR-T cells look like in the future?

In a few years time the next generation CAR-T cell therapies are going to look and behave very…

March 9, 2023
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A lysing kind of winter

Improving cell therapy performance with a multitude of innovative strategies

March 7, 2023
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Moving targets

Ten emerging development areas to watch out for in oncology during 2023

January 5, 2023
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Emerging biotechs and novel IO concepts to watch out for

10 early stage IO biotechs to watch out for

November 30, 2022
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SITC Preview 2 – a look at novel and emerging IO targets

Five areas of early stage IO developments to watch out for

October 14, 2022
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Up and coming cell therapy companies to watch out for

What can we learn from a raft of early cell therapy companies with novel or intriguing approaches?

May 24, 2022
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Revelations

New CAR-T cell developments in solid tumours - hit or miss?

April 24, 2022
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An inconvenient truth

Looking beyond the hype from a broader perspective

April 18, 2022
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The paradox of immune cell populations and transcription factors

Can you have your immune cake and eat it?

March 23, 2022
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Washington DC in Fall

SITC21 – What to Watch out for

SITC 2021 Preview

October 22, 2021
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TRIPLE highlights and lowlights in Developmental Therapeutics

The trials and tribulations of targeted agents in developmental therapeutics

October 25, 2020
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Advent of a new era in advanced prostate cancer treatment

A look at the first anti-cancer therapy with a radiopharmaceutical in advanced prostate cancer

June 3, 2021
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Dancing with proteins at the Masquerade

Who's going to the masquerade ball and how might they fare in the future?

June 1, 2021
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Off the Beaten ASCO21 Track Part 1

Hidden early stage gems to watch out for at ASCO21

May 25, 2021
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When PARP and immunotherapy worlds collide

New research is emerging which may have an impact on future trial designs as well as combination partners and even different tumour types.

May 12, 2021
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The Future of Cell and Gene Therapies

13 ways in which CAR based or gene therapies can improve on current approaches to cell therapies

April 22, 2021
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Novel approaches to cell therapies – Part 1

A look at switchable CAR-T cell therapies, plus CARs based on alternative immune cells.

April 19, 2021
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Fifteen AACR21 On Demand Presentations To Watch

Noteworthy AACR21 on-demand presentations.

March 23, 2021
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Highlights from Mini Oral Sessions at ESMO20

Commentary on Day 1 at ESMO20 and data presented in the mini oral sessions

September 19, 2020
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ESMO20 Preview 3 Developmental Therapeutics – IO therapies

Five IO areas in early stage development to watch out for at ESMO20

September 15, 2020
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Putting NK cells to work

Can we make NK cells work harder with gene editing? It looks as though this will be a feasible strategy to pursue...

July 7, 2020
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Will a novel way to target IL–18 be a winner?

Will we have more success targeting IL-18 to boost anti-tumour immunoty than other cytokines?

June 29, 2020
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Engineering Immunity – what did we learn from ASGCT20?

There are some creative and innovative new CAR T cell therapy designs being developed - what are they and where will they be tested?

May 14, 2020
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ASGCT20 Gems from the ePoster Hall

Review of 12 posters that caught our attention in the ePoster Hall at ASGCT20

May 14, 2020
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AACR20 – Ten New Directions in Early Cancer Drug Development

Ten intriguing novel agents in early development to watch out for

April 23, 2020
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Exploring the immunological links between lung cancer and Covid–19

Some immune cells overlap in cancer and Covid-19 so what can we learn from them in order to make an impact?

March 31, 2020
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The Best Clinical Data at SITC wasn’t NextCure’s NC318 Siglec–15

Analysis and commentary of Nektar's IL-2 cytokine bempeg in combination with nivolumab in 1L advanced melanoma

November 11, 2019
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Waves and waves of T cells

What can we learn from biomarkers and immune profiling in patients receiving bempeg, a CD122-directed pegylated IL-2 therapy

June 27, 2019
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Navigating new opportunities in the IL-2 space

How is Synthorx's IL-2 cytokine THOR-707 different from other compounds in this niche?

June 26, 2019
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How failure allows us to continually innovate

How the design of different cancer approaches can affect clinical performance

June 24, 2019
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Alternative approaches to targeting cytokines

Can we employ red blood cells in allogeneic, off-the-shelf cellular therapy products for the treatment of cancer?

June 19, 2019
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New developments in cytokines as immune modulators

New insights emerging from research on cytokines as an effective way to induce anti tumour immunity

January 31, 2019
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Pinning down potential new opportunities for IL–8 and 4–1BB

What is old is new again - a look at some forgotten oncology targets that are coming back in fashion

November 13, 2018
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An analysis of Nektar’s latest PIVOT data and pipeline update

Update on PIVOT-02 with nivolumab plus NKTR-214 in 1L metastatic melanoma

November 12, 2018
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Learnings from IO combinations and where we’re headed

Lessons learned from recent failure and a look at where a few new developments might be coming from...

August 23, 2018
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Armored CAR-T cell therapies and commercial threats from the East

On launched products, armored CARs and the potential threat from China

August 16, 2018
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In a Prudential Light

Bringing together disparate notes on cytokines and how they can be useful as an immunotherapy partner.

June 19, 2018
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The Potential for Cytokines in Cancer Immunotherapy

The latest part in our cytokine mini-series explores the potential for incorporating them in CARs or combining with checkpoint blockade through the lens of an expert in the field...

June 18, 2018
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How should we interpret the NKTR–214 data presented at ASCO?

What can we learn from the updated Nektar NKTR-214 data presented at #ASCO18?

June 14, 2018
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Stacking up evidence from IO clinical trials

A look at various lessons from recent IO trials and how they can applied to new readouts expected at ASCO18

May 3, 2018
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Bench to bedside and back again

A look at how basic and translational evidence points towards TGFβ as a possible new target for IO combos in some tumour types

May 1, 2018
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Targeting TGF-β and the tumour microenvironment

A look at one way with which we can target the tumour microenviroment to improve response of cancer immunotherapy

April 30, 2018
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Targeting NK cells effectively in AML

A look at targeting NK cells with immune agonists, cytokines and adoptive cell therapies

March 14, 2018
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Update on cytokines as novel cancer immunotherapy

A look at innate approaches to stimulating the immune system including IL-15 agonists

February 21, 2018
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Nektar hits it out of the park at SITC 2017

A look at Nektar's promising IO portfolio and what's next for the up and coming biotech

November 13, 2017
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National Harbor from Gaylord Hotel

SITC17 – Final Look at what to watch out for

Final SITC17 Preview and a look at key talks now that the abstracts are available.

November 8, 2017
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A look at Nektar Therapeutics immunotherapy pipeline

Update on Nektar Therapeutics IO portfolio and a look at their burgeoning autoimmune disorder pipeline

July 24, 2017
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SITC 2016 Can Nektar Boost Checkpoint Performance

Without effector T cells in the tumour, checkpoints won't work. So how do we attract more in? Here's one way to do it...

November 16, 2016