Biotech Strategy Blog

Commentary on Science, Innovation & New Products with a focus on Oncology, Hematology & Immunotherapy

Posts tagged ‘Adicet Bio’

For over a decade, cell therapy in cancer has embraced a simple philosophy: maximum firepower to eliminate malignant cells.

As these powerful tools enter autoimmune disease trials, however, a fascinating evolution is underway as companies begin releasing research on their pipelines at conferences.

Are the data breathing fire – or even too much of it?

From the early groundbreaking lupus studies to more precision targeting tools coming through preclinical development, researchers are discovering that finesse may well trump force when it comes to treating chronic inflammatory conditions.

This shift – from indiscriminate B cell destruction to more selective targeting of disease-driving cells – could redefine how we reset dysfunctional immune systems.

New data from the American College of Rheumatology (ACR) meeting held this week in Washington DC showcases this transformation while highlighting innovative approaches under the radar, which may finally thread the needle between efficacy and safety.

To continue reading our latest highlights on oncology new product development including commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

Choices, choices…

During the ongoing American College of Rheumatology (ACR24) conference held in Washington DC, there has been a wide choice of potential new treatments being investigated in refractory autoimmune diseases with several products from the oncology space.

These include bispecific T cell engagers, ex vivo and in vivo CAR-Ts, CAR-NKs, TCRs, and even ADCs.

There’s always more than one way to skin a cat – yet do they all look the same or even produce similar results?

In our latest in-depth look at the emerging preclinical and clinical data, we highlight quite a few red and green flags to watch out for in Part 1 of our ACR coverage…

To continue reading our latest highlights on oncology new product development including commentary and analysis BSB subscribers can log-in or you can click to access the content.

This content is restricted to subscribers

We’re at the point in time in the cancer conference calendar where we are rolling out AACR analyses and interviews while also highlighting relevant ASCO abstracts to watch out for.

As a result, I always tend to think of May as the ‘mish mash’ month, to put things in Brit speak.

This isn’t necessarily a negative connotation, by the by, rather it’s a great opportunity to highlight some developments in different niches which tended to be overlooked.

Sometimes new data allows us to put a more coherent picture together or set boundaries around the corporate messaging.

To kick start our ASCO coverage, we’ve taken five phase 1 trials and looked at the pros and cons of each in the context of the underlying science – some come out strongly or understated, others much less so.  It’s important to understand the underpinnings in order to avoid being sucked into the inevitable hype machine accompanying abstracts at this event…

BSB subscribers can read our latest post conference coverage from AACR plus commentary and analysis – you can either log-in or click to access.

This content is restricted to subscribers

Not in San Diego: We took a close look at the potential for targeting gamma delta (𝞬𝝳) T cells early last year in an extended mini-series looking at the landscape including some of the early companies leading the way in this niche.

Since then there’s been a raft of company related announcements and collaborations in recent months, highlighting the ongoing interest in this field.

In this post, it’s time to revisit the original landscape (link), as well as explore how well some of the biotech companies who are active in this space are navigating the R&D roller coaster.

We will also be discussing recent data presented at the AACR20 virtual meetings.

So what did we learn about gamma delta T Cell therapies at AACR20 – who stands out from the increasingly crowded pack?

To learn more from our oncology analysis and get a heads up on insights and commentary emerging from the AACR meeting, subscribers can log-in or you can click to gain access to BSB Premium Content.

This content is restricted to subscribers

error: Content is protected !!